Expression of SMIM6 in cancer - Summary - The Human Protein Atlas

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SMIM6

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SMIM6
Gene description	Small integral membrane protein 6
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (A549, EFO-21, HEL)
HPA (normal tissue):	Tissue enhanced (fallopian tube, stomach)

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA065721
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable), urothelial cancer (favourable) and renal cancer (favourable).
Endometrial cancer p<0.001 Urothelial cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA065721

GENE INFORMATION
Gene name	SMIM6 (HGNC Symbol)
Synonyms	C17orf110
Description	Small integral membrane protein 6 (HGNC Symbol)
Entrez gene summary
Chromosome	17
Cytoband	q25.1
Chromosome location (bp)	75646243 - 75647977
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000259120 (version 83.38)
Entrez gene	100130933
UniProt	P0DI80 (UniProt - Predicted)
neXtProt	NX_P0DI80
Antibodypedia	SMIM6 antibodies

PROTEIN BROWSER

SMIM6-001	SMIM6-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SMIM6-001 ENSP00000463361 ENST00000579469	P0DI80 [Direct mapping] Small integral membrane protein 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	62 aa 7 kDa	No	1
SMIM6-002 ENSP00000450581 ENST00000556126	P0DI80 [Direct mapping] Small integral membrane protein 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	62 aa 7 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.