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Cancer-related genes CD markers Disease related genes FDA approved drug targets Plasma proteins Predicted membrane proteins Predicted secreted proteins
Group enriched (melanoma, renal cancer, thyroid cancer)
HPA (cell line):
Cell line enhanced (EFO-21, HEL, WM-115)
HPA (normal tissue):
Tissue enhanced (thyroid gland)
Protein evidence
Evidence at protein level
Protein expression normal tissue
Cytoplasmic expression in megakaryocytes and platelets.
ANTIBODY IHC RELIABILITY
Data reliability description
Secreted protein, tissue location of RNA and protein might differ and correlation is complex. External characterization data supports antibody staining but internal RNA data does not include megakaryocytes.
The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. [provided by RefSeq, Jul 2008]