Expression of GH1 in cancer - Summary - The Human Protein Atlas

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GH1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GH1
Gene description	Growth hormone 1
Protein class	Cancer-related genes Candidate cardiovascular disease genes Disease related genes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Cell line enhanced (U-698)
HPA (normal tissue):	Tissue enhanced (placenta)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in cells in anterior pituitary gland and placenta.

ANTIBODY IHC RELIABILITY
Data reliability description	Caution, targets protein from more than one gene. Antibody staining mainly consistent with external characterization data and GTEx RNA expression data.
Reliability score	Supported based on 1 antibody. HPA043715
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA043715

GENE INFORMATION
Gene name	GH1 (HGNC Symbol)
Synonyms	GH, GH-N, GHN, hGH-N
Description	Growth hormone 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q23.3
Chromosome location (bp)	63917200 - 63918838
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000259384 (version 83.38)
Entrez gene	2688
UniProt	P01241 (UniProt - Evidence at protein level)
neXtProt	NX_P01241
Antibodypedia	GH1 antibodies

PROTEIN BROWSER

GH1-001	GH1-003	GH1-004	GH1-201	GH1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GH1-001 ENSP00000312673 ENST00000323322	P01241 [Direct mapping] Somatotropin B1A4G6 [Target identity:100%; Query identity:100%] Growth hormone 1 isoform 1; HCG1749481, isoform CRA_s Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes Show all	GO:0005131 [growth hormone receptor binding] GO:0005148 [prolactin receptor binding] GO:0005179 [hormone activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005622 [intracellular] GO:0007259 [JAK-STAT cascade] GO:0008083 [growth factor activity] GO:0010535 [positive regulation of activation of JAK2 kinase activity] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0015758 [glucose transport] GO:0032355 [response to estradiol] GO:0040018 [positive regulation of multicellular organism growth] GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein] GO:0042523 [positive regulation of tyrosine phosphorylation of Stat5 protein] GO:0043406 [positive regulation of MAP kinase activity] GO:0043568 [positive regulation of insulin-like growth factor receptor signaling pathway] GO:0046427 [positive regulation of JAK-STAT cascade] GO:0046872 [metal ion binding] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0060396 [growth hormone receptor signaling pathway] GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway] GO:0070977 [bone maturation] Show all	217 aa 24.8 kDa	Yes	0
GH1-003 ENSP00000408486 ENST00000458650	P01241 [Direct mapping] Somatotropin B1A4G7 [Target identity:100%; Query identity:100%] Growth hormone 1 isoform 2; HCG1749481, isoform CRA_aa Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes Show all	GO:0005131 [growth hormone receptor binding] GO:0005148 [prolactin receptor binding] GO:0005179 [hormone activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005622 [intracellular] GO:0007259 [JAK-STAT cascade] GO:0008083 [growth factor activity] GO:0010535 [positive regulation of activation of JAK2 kinase activity] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0015758 [glucose transport] GO:0032355 [response to estradiol] GO:0040018 [positive regulation of multicellular organism growth] GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein] GO:0042523 [positive regulation of tyrosine phosphorylation of Stat5 protein] GO:0043406 [positive regulation of MAP kinase activity] GO:0043568 [positive regulation of insulin-like growth factor receptor signaling pathway] GO:0046427 [positive regulation of JAK-STAT cascade] GO:0046872 [metal ion binding] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0060396 [growth hormone receptor signaling pathway] GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway] GO:0070977 [bone maturation] Show all	202 aa 23 kDa	Yes	0
GH1-004 ENSP00000343791 ENST00000351388	P01241 [Direct mapping] Somatotropin Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes Show all	GO:0005131 [growth hormone receptor binding] GO:0005148 [prolactin receptor binding] GO:0005179 [hormone activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005622 [intracellular] GO:0007259 [JAK-STAT cascade] GO:0008083 [growth factor activity] GO:0010535 [positive regulation of activation of JAK2 kinase activity] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0015758 [glucose transport] GO:0032355 [response to estradiol] GO:0040018 [positive regulation of multicellular organism growth] GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein] GO:0042523 [positive regulation of tyrosine phosphorylation of Stat5 protein] GO:0043406 [positive regulation of MAP kinase activity] GO:0043568 [positive regulation of insulin-like growth factor receptor signaling pathway] GO:0046427 [positive regulation of JAK-STAT cascade] GO:0046872 [metal ion binding] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0060396 [growth hormone receptor signaling pathway] GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway] GO:0070977 [bone maturation] Show all	177 aa 20.2 kDa	Yes	0
GH1-201 ENSP00000339278 ENST00000342364	B1A4G9 [Direct mapping] Growth hormone 1 isoform 4; HCG1749481, isoform CRA_g; Somatotropin Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005179 [hormone activity] GO:0005576 [extracellular region] Show all	122 aa 14 kDa	Yes	0
GH1-202 ENSP00000481276 ENST00000617086	B1A4H0 [Direct mapping] Growth hormone 1 isoform 5; Somatotropin Show all	Predicted intracellular proteins Show all		30 aa 3.5 kDa	No	0

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