Expression of HPR in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	HPR
Gene description	Haptoglobin-related protein
Protein class	Enzymes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (liver cancer)
HPA (cell line):	Cell line enriched (Hep G2)
HPA (normal tissue):	Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Granular cytoplasmic expression in liver with distinct positivity in plasma and extracellular matrix.

ANTIBODY IHC RELIABILITY
Data reliability description	Caution, targets protein from more than one gene. Antibody staining in cells/structures not annotated, view images.
Reliability score	Supported based on 1 antibody. HPA047750
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA047750

GENE INFORMATION
Gene name	HPR
Synonyms
Description	Haptoglobin-related protein (HGNC Symbol)
Entrez gene summary	This gene encodes a haptoglobin-related protein that binds hemoglobin as efficiently as haptoglobin. Unlike haptoglobin, plasma concentration of this protein is unaffected in patients with sickle cell anemia and extensive intravascular hemolysis, suggesting a difference in binding between haptoglobin-hemoglobin and haptoglobin-related protein-hemoglobin complexes to CD163, the hemoglobin scavenger receptor. This protein may also be a clinically important predictor of recurrence of breast cancer. [provided by RefSeq, Oct 2011]
Chromosome	16
Cytoband	q22.2
Chromosome location (bp)	72063224 - 72077246
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000261701 (version 83.38)
Entrez gene	3250
UniProt	P00739 (UniProt - Evidence at transcript level)
neXtProt	NX_P00739
Antibodypedia	HPR antibodies

PROTEIN BROWSER

HPR-001	HPR-002	HPR-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HPR-001 ENSP00000441828 ENST00000540303	P00739 [Direct mapping] Haptoglobin-related protein Show all	Enzymes Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002230 [positive regulation of defense response to virus by host] GO:0004252 [serine-type endopeptidase activity] GO:0005576 [extracellular region] GO:0006508 [proteolysis] GO:0006898 [receptor-mediated endocytosis] GO:0030492 [hemoglobin binding] GO:0034366 [spherical high-density lipoprotein particle] GO:0070062 [extracellular exosome] GO:0072562 [blood microparticle] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	348 aa 39 kDa	Yes	0
HPR-002 ENSP00000462916 ENST00000561690	J3KTC3 [Direct mapping] Haptoglobin-related protein Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		117 aa 13.3 kDa	Yes	0
HPR-201 ENSP00000349451 ENST00000356967	A0A0A0MRD9 [Direct mapping] Haptoglobin-related protein Show all	SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	281 aa 31.5 kDa	No	0