Expression of MIA in cancer - Summary - The Human Protein Atlas

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MIA

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	MIA
Gene description	Melanoma inhibitory activity
Protein class	Cancer-related genes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (melanoma)
HPA (cell line):	Group enriched (AN3-CA, CAPAN-2, SK-MEL-30, WM-115)
HPA (normal tissue):	Tissue enhanced (breast, stomach)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in breast cancer (favourable).
Breast cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (melanoma)

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	MIA (HGNC Symbol)
Synonyms	CD-RAP
Description	Melanoma inhibitory activity (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	q13.2
Chromosome location (bp)	40771648 - 40777490
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000261857 (version 83.38)
Entrez gene	8190
UniProt	Q16674 (UniProt - Evidence at protein level)
neXtProt	NX_Q16674
Antibodypedia	MIA antibodies

PROTEIN BROWSER

MIA-001	MIA-003	MIA-004	MIA-005	MIA-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MIA-001 ENSP00000263369 ENST00000263369	Q16674 [Direct mapping] Melanoma-derived growth regulatory protein A0A024R0P1 [Target identity:100%; Query identity:100%] HCG2043253, isoform CRA_a Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0008083 [growth factor activity] GO:0008283 [cell proliferation] Show all	131 aa 14.5 kDa	Yes	0
MIA-003 ENSP00000470129 ENST00000594436	Q16674 [Direct mapping] Melanoma-derived growth regulatory protein A0A024R0P1 [Target identity:100%; Query identity:100%] HCG2043253, isoform CRA_a Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0008083 [growth factor activity] GO:0008283 [cell proliferation] Show all	131 aa 14.5 kDa	Yes	0
MIA-004 ENSP00000469499 ENST00000597784	Q16674 [Direct mapping] Melanoma-derived growth regulatory protein A0A024R0P1 [Target identity:100%; Query identity:100%] HCG2043253, isoform CRA_a Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0008083 [growth factor activity] GO:0008283 [cell proliferation] Show all	131 aa 14.5 kDa	Yes	0
MIA-005 ENSP00000472982 ENST00000597600	M0R343 [Direct mapping] Melanoma-derived growth regulatory protein Show all	TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		46 aa 4.8 kDa	Yes	0
MIA-007 ENSP00000470641 ENST00000597140	M0QZM4 [Direct mapping] Melanoma-derived growth regulatory protein Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	95 aa 10.4 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.