Expression of CORO7 in cancer - Summary - The Human Protein Atlas

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CORO7

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CORO7
Gene description	Coronin 7
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	14
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues including bone marrow.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Uncertain based on 2 antibodies. HPA041657 , HPA053586
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable) and cervical cancer (favourable).
Endometrial cancer p<0.001 Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA041657	HPA053586

GENE INFORMATION
Gene name	CORO7 (HGNC Symbol)
Synonyms	FLJ22021
Description	Coronin 7 (HGNC Symbol)
Entrez gene summary	Coronins, such as CORO7, constitute an evolutionarily conserved family of WD-repeat actin-binding proteins. CORO7 plays a role in Golgi complex morphology and function (Rybakin et al., 2004, 2006 [PubMed 15327992] [PubMed 16905771]).[supplied by OMIM, Mar 2008]
Chromosome	16
Cytoband	p13.3
Chromosome location (bp)	4354542 - 4425705
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000262246 (version 83.38)
Entrez gene	79585
UniProt	P57737 (UniProt - Evidence at protein level)
neXtProt	NX_P57737
Antibodypedia	CORO7 antibodies

PROTEIN BROWSER

CORO7-001	CORO7-004	CORO7-009	CORO7-012	CORO7-014	CORO7-015	CORO7-016	CORO7-017	CORO7-018	CORO7-019	CORO7-020	CORO7-021	CORO7-026	CORO7-031

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CORO7-001 ENSP00000251166 ENST00000251166	P57737 [Direct mapping] Coronin-7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005794 [Golgi apparatus] GO:0005802 [trans-Golgi network] GO:0005829 [cytosol] GO:0006895 [Golgi to endosome transport] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0030041 [actin filament polymerization] Show all	925 aa 100.6 kDa	No	0
CORO7-004 ENSP00000440460 ENST00000537233	P57737 [Direct mapping] Coronin-7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005794 [Golgi apparatus] GO:0005802 [trans-Golgi network] GO:0005829 [cytosol] GO:0006895 [Golgi to endosome transport] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0030041 [actin filament polymerization] Show all	907 aa 98.6 kDa	No	0
CORO7-009 ENSP00000461702 ENST00000574025	P57737 [Direct mapping] Coronin-7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005794 [Golgi apparatus] GO:0005802 [trans-Golgi network] GO:0005829 [cytosol] GO:0006895 [Golgi to endosome transport] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0030041 [actin filament polymerization] Show all	840 aa 91.7 kDa	No	0
CORO7-012 ENSP00000459401 ENST00000573165	I3L258 [Direct mapping] Coronin-7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005794 [Golgi apparatus] Show all	19 aa 2.4 kDa	No	0
CORO7-014 ENSP00000461797 ENST00000575038	I3NI06 [Direct mapping] Coronin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005794 [Golgi apparatus] Show all	201 aa 22.2 kDa	No	0
CORO7-015 ENSP00000460910 ENST00000575850	I3L426 [Direct mapping] Coronin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005794 [Golgi apparatus] Show all	206 aa 22.1 kDa	No	0
CORO7-016 ENSP00000459286 ENST00000572549	I3L212 [Direct mapping] Coronin-7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005794 [Golgi apparatus] Show all	206 aa 23.1 kDa	No	0
CORO7-017 ENSP00000460036 ENST00000571059	I3L2Y6 [Direct mapping] Coronin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005794 [Golgi apparatus] Show all	157 aa 17.8 kDa	No	0
CORO7-018 ENSP00000458935 ENST00000572898	I3L1M1 [Direct mapping] Coronin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005794 [Golgi apparatus] Show all	161 aa 17.7 kDa	No	0
CORO7-019 ENSP00000460901 ENST00000570645	I3L423 [Direct mapping] Coronin-7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005794 [Golgi apparatus] Show all	47 aa 5.3 kDa	No	0
CORO7-020 ENSP00000459085 ENST00000571052	I3L1T5 [Direct mapping] Coronin-7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005794 [Golgi apparatus] Show all	57 aa 6.3 kDa	No	0
CORO7-021 ENSP00000458411 ENST00000572044	I3L0X8 [Direct mapping] Coronin-7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005794 [Golgi apparatus] Show all	162 aa 18.4 kDa	No	0
CORO7-026 ENSP00000459888 ENST00000576051	I3L2S7 [Direct mapping] Coronin-7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005794 [Golgi apparatus] Show all	11 aa 1.1 kDa	No	0
CORO7-031 ENSP00000460956 ENST00000570779	I3L442 [Direct mapping] Coronin-7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005794 [Golgi apparatus] Show all	190 aa 21.4 kDa	No	0

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