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MRPL12

GENERAL INFORMATION

Gene name

 MRPL12

Gene description

 Mitochondrial ribosomal protein L12

Protein class

 Predicted intracellular proteins
Ribosomal proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 2 antibodies.
HPA022853 , HPA023043
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PROGNOSTIC SUMMARY
Prognostic marker in lung cancer (unfavourable).
Lung cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA022853
HPA023043

GENE INFORMATION

Gene name

 MRPL12 (HGNC Symbol)

Synonyms

 MRPL7, MRPL7/L12, RPML12

Description

 Mitochondrial ribosomal protein L12 (HGNC Symbol)

Entrez gene summary

 Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which forms homodimers. In prokaryotic ribosomes, two L7/L12 dimers and one L10 protein form the L8 protein complex. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q25.3

Chromosome location (bp)

 81703357 - 81707526

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000262814 (version 83.38)

Entrez gene

 6182

UniProt

 P52815 (UniProt - Evidence at protein level)

neXtProt

 NX_P52815

Antibodypedia

 MRPL12 antibodies

PROTEIN BROWSER
MRPL12-001
MRPL12-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MRPL12-001
ENSP00000333837
ENST00000333676
P52815 [Direct mapping]
39S ribosomal protein L12, mitochondrial
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Ribosomal proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003723 [RNA binding]
GO:0003735 [structural constituent of ribosome]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005762 [mitochondrial large ribosomal subunit]
GO:0005840 [ribosome]
GO:0006390 [transcription from mitochondrial promoter]
GO:0006412 [translation]
GO:0006996 [organelle organization]
GO:0032543 [mitochondrial translation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0070124 [mitochondrial translational initiation]
GO:0070125 [mitochondrial translational elongation]
GO:0070126 [mitochondrial translational termination]
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 198 aa
21.3 kDa 		No 0
MRPL12-201
ENSP00000439565
ENST00000541223
F6QW41 [Direct mapping]
39S ribosomal protein L12, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003735 [structural constituent of ribosome]
GO:0005622 [intracellular]
GO:0005840 [ribosome]
GO:0006412 [translation]
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 178 aa
19.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.