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Malignant tissues showed moderate to strong nuclear positivity. A few cases of melanomas, renal cell carcinomas and stomach cancers displayed additional cytoplasmic immunoreactivity.
This gene encodes a member of a family of proteins containing a ribonucleoprotein (RNP)-type RNA binding motif and a carboxyl-terminal arginine-serine-rich (RS) domain. The encoded protein functions as a pre-mRNA splicing factor. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]