Fields »
ABOUT
HELP
BLOG
IKBKE

GENERAL INFORMATION

Gene name

 IKBKE

Gene description

 Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA015788 , CAB025983
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA015788
CAB025983

GENE INFORMATION

Gene name

 IKBKE (HGNC Symbol)

Synonyms

 IKK-i, IKKE, KIAA0151

Description

 Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon (HGNC Symbol)

Entrez gene summary

 IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 [PubMed 19481526]).[supplied by OMIM, Oct 2009]

Chromosome

 1

Cytoband

 q32.1

Chromosome location (bp)

 206470476 - 206496889

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000263528 (version 83.38)

Entrez gene

 9641

UniProt

 Q14164 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14164

Antibodypedia

 IKBKE antibodies

PROTEIN BROWSER
IKBKE-001
IKBKE-003
IKBKE-004
IKBKE-005
IKBKE-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IKBKE-001
ENSP00000464030
ENST00000581977
Q14164 [Direct mapping]
Inhibitor of nuclear factor kappa-B kinase subunit epsilon
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0002224 [toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004704 [NF-kappaB-inducing kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006955 [immune response]
GO:0007252 [I-kappaB phosphorylation]
GO:0008384 [IkappaB kinase activity]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0010008 [endosome membrane]
GO:0016605 [PML body]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031966 [mitochondrial membrane]
GO:0032480 [negative regulation of type I interferon production]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034340 [response to type I interferon]
GO:0035456 [response to interferon-beta]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0036435 [K48-linked polyubiquitin binding]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045087 [innate immune response]
GO:0051260 [protein homooligomerization]
GO:0098586 [cellular response to virus]
Show all
 716 aa
80.5 kDa 		No 0
IKBKE-003
ENSP00000462396
ENST00000584998
Q14164 [Direct mapping]
Inhibitor of nuclear factor kappa-B kinase subunit epsilon
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0002224 [toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004704 [NF-kappaB-inducing kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006955 [immune response]
GO:0007252 [I-kappaB phosphorylation]
GO:0008384 [IkappaB kinase activity]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0010008 [endosome membrane]
GO:0016605 [PML body]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031966 [mitochondrial membrane]
GO:0032480 [negative regulation of type I interferon production]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0035456 [response to interferon-beta]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0036435 [K48-linked polyubiquitin binding]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045087 [innate immune response]
GO:0051260 [protein homooligomerization]
Show all
 631 aa
70.8 kDa 		No 0
IKBKE-004
ENSP00000473833
ENST00000578328
A0A075B7B4 [Direct mapping]
Inhibitor of nuclear factor kappa-B kinase subunit epsilon
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 657 aa
73.7 kDa 		No 0
IKBKE-005
ENSP00000474229
ENST00000605726
A0A075B7C7 [Direct mapping]
Inhibitor of nuclear factor kappa-B kinase subunit epsilon
Show all
Predicted intracellular proteins
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 146 aa
16.4 kDa 		No 0
IKBKE-006
ENSP00000474422
ENST00000579827
A0A075B7D5 [Direct mapping]
Inhibitor of nuclear factor kappa-B kinase subunit epsilon
Show all
Predicted intracellular proteins
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 153 aa
16.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.