Expression of MSMB in cancer - Summary - The Human Protein Atlas

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MSMB

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MSMB
Gene description	Microseminoprotein, beta-
Protein class	Cancer-related genes Disease related genes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (prostate cancer)
HPA (cell line):	Cell line enhanced (BEWO, NB-4, RPMI-8226, U-2197)
HPA (normal tissue):	Tissue enriched (prostate)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Glandular cytoplasmic expression in prostate and stomach.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Supported based on 2 antibodies. HPA051257 , CAB026357
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (favourable).
Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (prostate cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA051257	CAB026357

GENE INFORMATION
Gene name	MSMB (HGNC Symbol)
Synonyms	IGBF, MSP, MSPB, PN44, PRPS, PSP, PSP-94, PSP57, PSP94
Description	Microseminoprotein, beta- (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the immunoglobulin binding factor family. It is synthesized by the epithelial cells of the prostate gland and secreted into the seminal plasma. This protein has inhibin-like activity. It may have a role as an autocrine paracrine factor in uterine, breast and other female reproductive tissues. The expression of the encoded protein is found to be decreased in prostate cancer. Two alternatively spliced transcript variants encoding different isoforms are described for this gene. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	10
Cytoband	q11.22
Chromosome location (bp)	46033307 - 46046269
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000263639 (version 83.38)
Entrez gene	4477
UniProt	P08118 (UniProt - Evidence at protein level)
neXtProt	NX_P08118
Antibodypedia	MSMB antibodies

PROTEIN BROWSER

MSMB-001	MSMB-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MSMB-001 ENSP00000463092 ENST00000582163	P08118 [Direct mapping] Beta-microseminoprotein Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0008150 [biological_process] Show all	114 aa 12.9 kDa	Yes	0
MSMB-201 ENSP00000462641 ENST00000581478	P08118 [Direct mapping] Beta-microseminoprotein Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0008150 [biological_process] Show all	77 aa 8.8 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.