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GDF2

GENERAL INFORMATION

Gene name

 GDF2

Gene description

 Growth differentiation factor 2

Protein class

 Disease related genes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Not detected
HPA (cell line):Not detected
HPA (normal tissue):Tissue enriched (liver)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
CAB023357
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
CAB023357

GENE INFORMATION

Gene name

 GDF2 (HGNC Symbol)

Synonyms

 BMP-9, BMP9

Description

 Growth differentiation factor 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in rodents suggest that this protein plays a role in the adult liver and in differentiation of cholinergic central nervous system neurons. Mutations in this gene are associated with hereditary hemorrhagic telangiectasia. [provided by RefSeq, Jan 2014]

Chromosome

 10

Cytoband

 q11.22

Chromosome location (bp)

 47322490 - 47326270

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000263761 (version 83.38)

Entrez gene

 2658

UniProt

 Q9UK05 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UK05

Antibodypedia

 GDF2 antibodies

PROTEIN BROWSER
GDF2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GDF2-001
ENSP00000463051
ENST00000581492
Q9UK05 [Direct mapping]
Growth/differentiation factor 2
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
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GO:0001503 [ossification]
GO:0001525 [angiogenesis]
GO:0001569 [patterning of blood vessels]
GO:0001570 [vasculogenesis]
GO:0001649 [osteoblast differentiation]
GO:0001937 [negative regulation of endothelial cell proliferation]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0005125 [cytokine activity]
GO:0005160 [transforming growth factor beta receptor binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005623 [cell]
GO:0006879 [cellular iron ion homeostasis]
GO:0008083 [growth factor activity]
GO:0008156 [negative regulation of DNA replication]
GO:0010596 [negative regulation of endothelial cell migration]
GO:0010628 [positive regulation of gene expression]
GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation]
GO:0016525 [negative regulation of angiogenesis]
GO:0030308 [negative regulation of cell growth]
GO:0030509 [BMP signaling pathway]
GO:0030513 [positive regulation of BMP signaling pathway]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0032924 [activin receptor signaling pathway]
GO:0040007 [growth]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
GO:0043537 [negative regulation of blood vessel endothelial cell migration]
GO:0045603 [positive regulation of endothelial cell differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045766 [positive regulation of angiogenesis]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048468 [cell development]
GO:0048514 [blood vessel morphogenesis]
GO:0051216 [cartilage development]
GO:0060389 [pathway-restricted SMAD protein phosphorylation]
GO:0060395 [SMAD protein signal transduction]
GO:0061036 [positive regulation of cartilage development]
GO:0070062 [extracellular exosome]
GO:0071773 [cellular response to BMP stimulus]
GO:2000279 [negative regulation of DNA biosynthetic process]
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 429 aa
47.3 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.