Expression of ANXA8L1 in cancer - Summary - The Human Protein Atlas

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ANXA8L1

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	ANXA8L1
Gene description	Annexin A8-like 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (HaCaT, hTCEpi, SiHa)
HPA (normal tissue):	Group enriched (esophagus, skin)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	ANXA8L1 (HGNC Symbol)
Synonyms	ANXA8L2, bA145E20.2, bA301J7.3
Description	Annexin A8-like 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the annexin family of evolutionarily conserved Ca2+ and phospholipid binding proteins. The encoded protein may function as an an anticoagulant that indirectly inhibits the thromboplastin-specific complex. Overexpression of this gene has been associated with acute myelocytic leukemia. A highly similar duplicated copy of this gene is found in close proximity on the long arm of chromosome 10. [provided by RefSeq, Apr 2014]
Chromosome	10
Cytoband	q11.22
Chromosome location (bp)	46375627 - 46537864
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000264230 (version 83.38)
Entrez gene	728113
UniProt	Q5VT79 (UniProt - Evidence at transcript level)
neXtProt	NX_Q5VT79
Antibodypedia	ANXA8L1 antibodies

PROTEIN BROWSER

ANXA8L1-001	ANXA8L1-002	ANXA8L1-003	ANXA8L1-201	ANXA8L1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ANXA8L1-001 ENSP00000483608 ENST00000622769	Q5VT79 [Direct mapping] Annexin A8-like protein 1 A0A0B4J2F9 [Direct mapping] Annexin Show all	Predicted intracellular proteins Show all	GO:0005509 [calcium ion binding] GO:0005544 [calcium-dependent phospholipid binding] GO:0070062 [extracellular exosome] Show all	276 aa 30.7 kDa	No	0
ANXA8L1-002 ENSP00000480221 ENST00000619162	Q5VT79 [Direct mapping] Annexin A8-like protein 1 Show all	Predicted intracellular proteins Show all	GO:0005509 [calcium ion binding] GO:0005544 [calcium-dependent phospholipid binding] GO:0070062 [extracellular exosome] Show all	327 aa 36.9 kDa	No	0
ANXA8L1-003 ENSP00000484310 ENST00000611655	B4DTF2 [Direct mapping] Annexin Show all	Predicted intracellular proteins Show all	GO:0005509 [calcium ion binding] GO:0005544 [calcium-dependent phospholipid binding] Show all	270 aa 30.5 kDa	No	0
ANXA8L1-201 ENSP00000462716 ENST00000584982	A0A075B752 [Direct mapping] Annexin Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Show all	GO:0005509 [calcium ion binding] GO:0005544 [calcium-dependent phospholipid binding] Show all	365 aa 40.7 kDa	No	0
ANXA8L1-202 ENSP00000478808 ENST00000613703	A0A087WUP0 [Direct mapping] Annexin Show all	Predicted intracellular proteins Show all	GO:0005509 [calcium ion binding] GO:0005544 [calcium-dependent phospholipid binding] Show all	265 aa 30 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.