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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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MYH4
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    TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

MYH4

Gene description

Myosin, heavy chain 4, skeletal muscle

Protein class

Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Tissue enriched (liver cancer)
HPA (cell line):Not detected
HPA (normal tissue):Tissue enriched (skeletal muscle)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in skeletal muscle and heart muscle.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

Supported based on 1 antibody.
HPA001349
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PROGNOSTIC SUMMARY

Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA001349

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer cells were negative.

GENE INFORMATION

Gene name

MYH4 (HGNC Symbol)

Synonyms

MYH2B, MyHC-2B, MyHC-IIb

Description

Myosin, heavy chain 4, skeletal muscle (HGNC Symbol)

Entrez gene summary

Chromosome

17

Cytoband

p13.1

Chromosome location (bp)

10443290 - 10469559

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000264424 (version 83.38)

Entrez gene

4622

UniProt

Q9Y623 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y623

Antibodypedia

MYH4 antibodies

PROTEIN BROWSER

MYH4-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MYH4-001
ENSP00000255381
ENST00000255381
Q9Y623 [Direct mapping]
Myosin-4
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000146 [microfilament motor activity]
GO:0003725 [double-stranded RNA binding]
GO:0003774 [motor activity]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005859 [muscle myosin complex]
GO:0006936 [muscle contraction]
GO:0014823 [response to activity]
GO:0016459 [myosin complex]
GO:0016887 [ATPase activity]
GO:0030016 [myofibril]
GO:0030017 [sarcomere]
GO:0030048 [actin filament-based movement]
GO:0030049 [muscle filament sliding]
GO:0032982 [myosin filament]
GO:0046034 [ATP metabolic process]
GO:0061024 [membrane organization]
Show all
1939 aa
223.1 kDa
No 0

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The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.