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ANXA8

GENERAL INFORMATION

Gene name

 ANXA8

Gene description

 Annexin A8

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (head and neck cancer)
HPA (cell line):Cell line enhanced (A-431, HaCaT, hTCEpi, RT4)
HPA (normal tissue):Tissue enhanced (esophagus, skin)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable) and head and neck cancer (unfavourable).
Pancreatic cancer p<0.001
Head and neck cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (head and neck cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 ANXA8 (HGNC Symbol)

Synonyms

 ANX8

Description

 Annexin A8 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the annexin family of evolutionarily conserved Ca2+ and phospholipid binding proteins. The encoded protein may function as an an anticoagulant that indirectly inhibits the thromboplastin-specific complex. Overexpression of this gene has been associated with acute myelocytic leukemia. A highly similar duplicated copy of this gene is found in close proximity on the long arm of chromosome 10. [provided by RefSeq, Jul 2008]

Chromosome

 10

Cytoband

 q11.22

Chromosome location (bp)

 47460162 - 47484158

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000265190 (version 83.38)

Entrez gene

 653145

UniProt

 P13928 (UniProt - Evidence at protein level)

neXtProt

 NX_P13928

Antibodypedia

 ANXA8 antibodies

PROTEIN BROWSER
ANXA8-001
ANXA8-002
ANXA8-004
ANXA8-201
ANXA8-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ANXA8-001
ENSP00000462880
ENST00000585281
P13928 [Direct mapping]
Annexin A8
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Predicted intracellular proteins
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GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007032 [endosome organization]
GO:0007596 [blood coagulation]
GO:0016197 [endosomal transport]
GO:0031902 [late endosome membrane]
GO:0043325 [phosphatidylinositol-3,4-bisphosphate binding]
GO:0051015 [actin filament binding]
GO:1900004 [negative regulation of serine-type endopeptidase activity]
GO:1900138 [negative regulation of phospholipase A2 activity]
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 327 aa
36.9 kDa 		No 0
ANXA8-002
ENSP00000464486
ENST00000583874
A0A075B765 [Direct mapping]
Annexin
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Predicted intracellular proteins
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GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
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 276 aa
30.7 kDa 		No 0
ANXA8-004
ENSP00000462181
ENST00000583448
A0A075B748 [Direct mapping]
Annexin A8
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Predicted intracellular proteins
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 21 aa
2.4 kDa 		No 0
ANXA8-201
ENSP00000463091
ENST00000583911
P13928 [Direct mapping]
Annexin A8
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Predicted intracellular proteins
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GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007032 [endosome organization]
GO:0007596 [blood coagulation]
GO:0016197 [endosomal transport]
GO:0031902 [late endosome membrane]
GO:0043325 [phosphatidylinositol-3,4-bisphosphate binding]
GO:0051015 [actin filament binding]
GO:1900004 [negative regulation of serine-type endopeptidase activity]
GO:1900138 [negative regulation of phospholipase A2 activity]
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 265 aa
30 kDa 		No 0
ANXA8-202
ENSP00000478026
ENST00000611843
A0A087WTN9 [Direct mapping]
Annexin
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
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GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
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 365 aa
40.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.