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RBM8A

GENERAL INFORMATION

Gene name

 RBM8A

Gene description

 RNA binding motif protein 8A

Protein class

 Plasma proteins
Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA018403
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PROGNOSTIC SUMMARY
Prognostic marker in prostate cancer (unfavourable).
Prostate cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA018403

GENE INFORMATION

Gene name

 RBM8A (HGNC Symbol)

Synonyms

 BOV-1A, BOV-1B, BOV-1C, RBM8, RBM8B, Y14, ZNRP

Description

 RNA binding motif protein 8A (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein with a conserved RNA-binding motif. The protein is found predominantly in the nucleus, although it is also present in the cytoplasm. It is preferentially associated with mRNAs produced by splicing, including both nuclear mRNAs and newly exported cytoplasmic mRNAs. It is thought that the protein remains associated with spliced mRNAs as a tag to indicate where introns had been present, thus coupling pre- and post-mRNA splicing events. Previously, it was thought that two genes encode this protein, RBM8A and RBM8B; it is now thought that the RBM8B locus is a pseudogene. There are two alternate translation start codons with this gene, which result in two forms of the protein. An allele mutation and a low-frequency noncoding single-nucleotide polymorphism (SNP) in this gene cause thrombocytopenia-absent radius (TAR) syndrome. [provided by RefSeq, Jul 2013]

Chromosome

 1

Cytoband

 q21.1

Chromosome location (bp)

 145917714 - 145927678

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000265241 (version 83.38)

Entrez gene

 9939

UniProt

 Q9Y5S9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y5S9

Antibodypedia

 RBM8A antibodies

PROTEIN BROWSER
RBM8A-001
RBM8A-002
RBM8A-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RBM8A-001
ENSP00000463058
ENST00000583313
Q9Y5S9 [Direct mapping]
RNA-binding protein 8A
A0A023T787 [Target identity:100%; Query identity:100%]
RNA-binding protein 8A
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Transporters
   Primary Active Transporters
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0000381 [regulation of alternative mRNA splicing, via spliceosome]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006369 [termination of RNA polymerase II transcription]
GO:0006406 [mRNA export from nucleus]
GO:0006417 [regulation of translation]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016607 [nuclear speck]
GO:0030425 [dendrite]
GO:0031124 [mRNA 3'-end processing]
GO:0035145 [exon-exon junction complex]
GO:0043025 [neuronal cell body]
GO:0044822 [poly(A) RNA binding]
GO:0071013 [catalytic step 2 spliceosome]
Show all
 174 aa
19.9 kDa 		No 0
RBM8A-002
ENSP00000358313
ENST00000369307
Q9Y5S9 [Direct mapping]
RNA-binding protein 8A
Show all
Transporters
   Primary Active Transporters
Predicted intracellular proteins
Plasma proteins
Show all
GO:0000166 [nucleotide binding]
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0000381 [regulation of alternative mRNA splicing, via spliceosome]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006369 [termination of RNA polymerase II transcription]
GO:0006406 [mRNA export from nucleus]
GO:0006417 [regulation of translation]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016607 [nuclear speck]
GO:0031124 [mRNA 3'-end processing]
GO:0035145 [exon-exon junction complex]
GO:0044822 [poly(A) RNA binding]
GO:0071013 [catalytic step 2 spliceosome]
Show all
 173 aa
19.8 kDa 		No 0
RBM8A-006
ENSP00000488265
ENST00000632555
Q9Y5S9 [Direct mapping]
RNA-binding protein 8A
A0A023T787 [Target identity:100%; Query identity:100%]
RNA-binding protein 8A
Show all
Transporters
   Primary Active Transporters
Predicted intracellular proteins
Plasma proteins
Show all
GO:0000166 [nucleotide binding]
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0000381 [regulation of alternative mRNA splicing, via spliceosome]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003729 [mRNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006369 [termination of RNA polymerase II transcription]
GO:0006406 [mRNA export from nucleus]
GO:0006417 [regulation of translation]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016607 [nuclear speck]
GO:0031124 [mRNA 3'-end processing]
GO:0035145 [exon-exon junction complex]
GO:0044822 [poly(A) RNA binding]
GO:0071013 [catalytic step 2 spliceosome]
Show all
 174 aa
19.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.