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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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AP000275.65
  • TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

AP000275.65

Gene description

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Not detected
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Cytoplasmic expression in most tissues, highest expression in reproductive organs and respiratory tract.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Pending external verification. Caution, targets protein from more than one gene.

Reliability score

Approved based on 2 antibodies.
HPA019055 , HPA028849
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PROGNOSTIC SUMMARY

Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA019055
HPA028849

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

A majority of endometrial and testicular cancers as well as several colorectal and ovarian cancers showed moderate cytoplasmic positivity. Remaining cancer tissues were generally negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cases of colorectal, ovarian, cervical, endometrial and testicular cancers displayed moderate cytoplasmic staining. Remaining cancer tissues were in general weakly stained or negative.

GENE INFORMATION

Gene name

AP000275.65

Synonyms

Description

Entrez gene summary

Chromosome

21

Cytoband

q22.11

Chromosome location (bp)

32578822 - 32612281

Protein evidence

Evidence at transcript level (all genes)

Ensembl

ENSG00000265590 (version 83.38)

Entrez gene

UniProt

neXtProt

Antibodypedia

AP000275.65 antibodies

PROTEIN BROWSER

AP000275.65-002
AP000275.65-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AP000275.65-002
ENSP00000446874
ENST00000553001
F8VZ95 [Direct mapping]
Uncharacterized protein
Show all
Predicted intracellular proteins
Show all
GO:0048858 [cell projection morphogenesis]
Show all
297 aa
33.8 kDa
No 0
AP000275.65-003
ENSP00000391771
ENST00000431216
H7BZW1 [Direct mapping]
Uncharacterized protein
Show all
Predicted intracellular proteins
Show all
GO:0048858 [cell projection morphogenesis]
Show all
297 aa
33.9 kDa
No 0

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The Human Protein Atlas project is funded
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