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RASSF5

GENERAL INFORMATION

Gene name

 RASSF5

Gene description

 Ras association (RalGDS/AF-6) domain family member 5

Protein class

 Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and membranous expression in most tissues. Highly expressed in spleen.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA070480
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Spleen

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 RASSF5 (HGNC Symbol)

Synonyms

 Maxp1, NORE1, RAPL

Description

 Ras association (RalGDS/AF-6) domain family member 5 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q32.1

Chromosome location (bp)

 206507530 - 206589283

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000266094 (version 83.38)

Entrez gene

 83593

UniProt

 Q8WWW0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8WWW0

Antibodypedia

 RASSF5 antibodies

PROTEIN BROWSER
RASSF5-001
RASSF5-002
RASSF5-003
RASSF5-004
RASSF5-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RASSF5-001
ENSP00000462099
ENST00000579436
Q8WWW0 [Direct mapping]
Ras association domain-containing protein 5
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Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005874 [microtubule]
GO:0006915 [apoptotic process]
GO:0007165 [signal transduction]
GO:0008285 [negative regulation of cell proliferation]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0035556 [intracellular signal transduction]
GO:0046872 [metal ion binding]
GO:1900180 [regulation of protein localization to nucleus]
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 418 aa
47.1 kDa 		No 0
RASSF5-002
ENSP00000462544
ENST00000580449
Q8WWW0 [Direct mapping]
Ras association domain-containing protein 5
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005874 [microtubule]
GO:0006915 [apoptotic process]
GO:0007165 [signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0046872 [metal ion binding]
Show all
 336 aa
37.4 kDa 		No 0
RASSF5-003
ENSP00000464039
ENST00000581503
A0A075B763 [Direct mapping]
Ras association domain-containing protein 5
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Predicted intracellular proteins
RAS pathway related proteins
Show all
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0046872 [metal ion binding]
Show all
 350 aa
39.1 kDa 		No 0
RASSF5-004
ENSP00000462576
ENST00000577571
Q8WWW0 [Direct mapping]
Ras association domain-containing protein 5
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005874 [microtubule]
GO:0006915 [apoptotic process]
GO:0007165 [signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0046872 [metal ion binding]
Show all
 265 aa
30.4 kDa 		No 0
RASSF5-005
ENSP00000474142
ENST00000581888
Q8TEK8 [Direct mapping]
FLJ00186 protein; Ras association domain-containing protein 5
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Predicted intracellular proteins
RAS pathway related proteins
Show all
GO:0007165 [signal transduction]
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 185 aa
20.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.