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STRADA

GENERAL INFORMATION

Gene name

 STRADA

Gene description

 STE20-related kinase adaptor alpha

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 16
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA031637
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), pancreatic cancer (favourable) and urothelial cancer (favourable).
Renal cancer p<0.001
Pancreatic cancer p<0.001
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA031637

GENE INFORMATION

Gene name

 STRADA (HGNC Symbol)

Synonyms

 LYK5, NY-BR-96, Stlk, STRAD

Description

 STE20-related kinase adaptor alpha (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known. [provided by RefSeq, Sep 2009]

Chromosome

 17

Cytoband

 q23.3

Chromosome location (bp)

 63702832 - 63741970

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000266173 (version 83.38)

Entrez gene

 92335

UniProt

 Q7RTN6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q7RTN6

Antibodypedia

 STRADA antibodies

PROTEIN BROWSER
«
STRADA-001
STRADA-003
STRADA-004
STRADA-005
STRADA-006
STRADA-007
STRADA-009
STRADA-010
STRADA-011
STRADA-012
STRADA-013
STRADA-016
STRADA-019
STRADA-020
STRADA-022
STRADA-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
STRADA-001
ENSP00000336655
ENST00000336174
Q7RTN6 [Direct mapping]
STE20-related kinase adapter protein alpha
Show all
Enzymes
   Kinases
   STE Ser/Thr protein kinases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006611 [protein export from nucleus]
GO:0007050 [cell cycle arrest]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0008286 [insulin receptor signaling pathway]
GO:0016477 [cell migration]
GO:0019900 [kinase binding]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030036 [actin cytoskeleton organization]
GO:0030295 [protein kinase activator activity]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
GO:0043539 [protein serine/threonine kinase activator activity]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
Show all
 431 aa
48.4 kDa 		No 0
STRADA-003
ENSP00000376677
ENST00000392950
Q7RTN6 [Direct mapping]
STE20-related kinase adapter protein alpha
Show all
Enzymes
   Kinases
   STE Ser/Thr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006611 [protein export from nucleus]
GO:0007050 [cell cycle arrest]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0008286 [insulin receptor signaling pathway]
GO:0016477 [cell migration]
GO:0019900 [kinase binding]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030036 [actin cytoskeleton organization]
GO:0030295 [protein kinase activator activity]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
GO:0043539 [protein serine/threonine kinase activator activity]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
Show all
 348 aa
38.6 kDa 		No 0
STRADA-004
ENSP00000398841
ENST00000447001
Q7RTN6 [Direct mapping]
STE20-related kinase adapter protein alpha
Show all
Enzymes
   Kinases
   STE Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006611 [protein export from nucleus]
GO:0007050 [cell cycle arrest]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0008286 [insulin receptor signaling pathway]
GO:0016477 [cell migration]
GO:0019900 [kinase binding]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030036 [actin cytoskeleton organization]
GO:0030295 [protein kinase activator activity]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
GO:0043539 [protein serine/threonine kinase activator activity]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
Show all
 299 aa
33.3 kDa 		No 0
STRADA-005
ENSP00000245865
ENST00000245865
Q86YC8 [Direct mapping]
STE20-related kinase adapter protein alpha; STRADA protein
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0016477 [cell migration]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030036 [actin cytoskeleton organization]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
Show all
 234 aa
26.1 kDa 		No 0
STRADA-006
ENSP00000462922
ENST00000582137
Q7RTN6 [Direct mapping]
STE20-related kinase adapter protein alpha
Show all
Enzymes
   Kinases
   STE Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006611 [protein export from nucleus]
GO:0007050 [cell cycle arrest]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0008286 [insulin receptor signaling pathway]
GO:0016477 [cell migration]
GO:0019900 [kinase binding]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030036 [actin cytoskeleton organization]
GO:0030295 [protein kinase activator activity]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
GO:0043539 [protein serine/threonine kinase activator activity]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
Show all
 314 aa
34.6 kDa 		No 0
STRADA-007
ENSP00000365000
ENST00000375840
Q7RTN6 [Direct mapping]
STE20-related kinase adapter protein alpha
Show all
Enzymes
   Kinases
   STE Ser/Thr protein kinases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006611 [protein export from nucleus]
GO:0007050 [cell cycle arrest]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0008286 [insulin receptor signaling pathway]
GO:0016477 [cell migration]
GO:0019900 [kinase binding]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030036 [actin cytoskeleton organization]
GO:0030295 [protein kinase activator activity]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
GO:0043539 [protein serine/threonine kinase activator activity]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
Show all
 373 aa
41.7 kDa 		No 0
STRADA-009
ENSP00000463203
ENST00000580338
J3QKR7 [Direct mapping]
STE20-related kinase adapter protein alpha
Show all
Predicted intracellular proteins
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0016477 [cell migration]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030036 [actin cytoskeleton organization]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
Show all
 78 aa
8.8 kDa 		No 0
STRADA-010
ENSP00000463238
ENST00000580288
J3QKU4 [Direct mapping]
STE20-related kinase adapter protein alpha
Show all
Predicted intracellular proteins
Show all
GO:0005622 [intracellular]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0016477 [cell migration]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030036 [actin cytoskeleton organization]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
Show all
 45 aa
5.3 kDa 		No 0
STRADA-011
ENSP00000462384
ENST00000579549
J3KSA2 [Direct mapping]
STE20-related kinase adapter protein alpha
Show all
Predicted intracellular proteins
Show all
GO:0005622 [intracellular]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0016477 [cell migration]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030036 [actin cytoskeleton organization]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
Show all
 72 aa
7.9 kDa 		No 0
STRADA-012
ENSP00000462496
ENST00000584110
A0A0G2JLH2 [Direct mapping]
STE20-related kinase adapter protein alpha
Show all
Predicted intracellular proteins
Show all
GO:0005622 [intracellular]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0016477 [cell migration]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030036 [actin cytoskeleton organization]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
Show all
 10 aa
1 kDa 		No 0
STRADA-013
ENSP00000464139
ENST00000582030
J3QRC1 [Direct mapping]
STE20-related kinase adapter protein alpha
Show all
Predicted intracellular proteins
Show all
GO:0005622 [intracellular]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0016477 [cell migration]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030036 [actin cytoskeleton organization]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
Show all
 50 aa
5.6 kDa 		No 0
STRADA-016
ENSP00000462530
ENST00000579340
J3KSK5 [Direct mapping]
STE20-related kinase adapter protein alpha
Show all
Predicted intracellular proteins
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0016477 [cell migration]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030036 [actin cytoskeleton organization]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
Show all
 173 aa
19.6 kDa 		No 0
STRADA-019
ENSP00000463872
ENST00000578801
J3QQS3 [Direct mapping]
STE20-related kinase adapter protein alpha
Show all
Predicted intracellular proteins
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0016477 [cell migration]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030036 [actin cytoskeleton organization]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
Show all
 131 aa
14.9 kDa 		No 0
STRADA-020
ENSP00000464547
ENST00000578008
J3QS66 [Direct mapping]
STE20-related kinase adapter protein alpha
Show all
Predicted intracellular proteins
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0016477 [cell migration]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030036 [actin cytoskeleton organization]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
Show all
 167 aa
18.6 kDa 		No 0
STRADA-022
ENSP00000464213
ENST00000582026
J3QRH3 [Direct mapping]
STE20-related kinase adapter protein alpha
Show all
Predicted intracellular proteins
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0016477 [cell migration]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030036 [actin cytoskeleton organization]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
Show all
 55 aa
6.2 kDa 		No 0
STRADA-201
ENSP00000481505
ENST00000617949
Q86YC8 [Direct mapping]
STE20-related kinase adapter protein alpha; STRADA protein
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0016477 [cell migration]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030036 [actin cytoskeleton organization]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
Show all
 234 aa
26.1 kDa 		No 0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.