Cell atlas - NCOA4 - The Human Protein Atlas

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NCOA4

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Golgi apparatus
	Nucleoli

Human cell
	Cytosol
	Golgi Apparatus
	Nucleoli

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GENERAL INFORMATION
Gene name	NCOA4
Gene description	Nuclear receptor coactivator 4
Protein class	Cancer-related genes Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoli. In addition localized to the cytosol & the Golgi apparatus.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli (approved)
Additional location	In addition localized to the Golgi apparatus (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA051260
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoli. In addition localized to the cytosol & the Golgi apparatus.

Main location

Nucleoli (approved)

Additional location

Golgi apparatus (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA051260	HeLa	Nucleoli
			Golgi apparatus
			Cytosol
	HPA051260	MCF7	Nucleoli
	HPA051260	U-2 OS	Nucleoli
	HPA051260	U-2 OS	Cytosol

GENE INFORMATION
Gene name	NCOA4 (HGNC Symbol)
Synonyms	ARA70, DKFZp762E1112, ELE1, PTC3, RFG
Description	Nuclear receptor coactivator 4 (HGNC Symbol)
Entrez gene summary	This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14. [provided by RefSeq, Feb 2009]
Chromosome	10
Cytoband	q11.22
Chromosome location (bp)	46005088 - 46030714
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000266412 (version 83.38)
Entrez gene	8031
UniProt	Q13772 (UniProt - Evidence at protein level)
neXtProt	NX_Q13772
Antibodypedia	NCOA4 antibodies

PROTEIN BROWSER

NCOA4-001	NCOA4-002	NCOA4-003	NCOA4-004	NCOA4-005	NCOA4-006	NCOA4-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NCOA4-001 ENSP00000463027 ENST00000578454	Q13772 [Direct mapping] Nuclear receptor coactivator 4 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0003713 [transcription coactivator activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0008584 [male gonad development] GO:0009725 [response to hormone] GO:0030521 [androgen receptor signaling pathway] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0050681 [androgen receptor binding] Show all	650 aa 73.6 kDa	No	0
NCOA4-002 ENSP00000463455 ENST00000579039	Q13772 [Direct mapping] Nuclear receptor coactivator 4 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0003713 [transcription coactivator activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0008584 [male gonad development] GO:0030521 [androgen receptor signaling pathway] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0050681 [androgen receptor binding] Show all	630 aa 71.4 kDa	No	0
NCOA4-003 ENSP00000463022 ENST00000585056	B4DF87 [Direct mapping] Nuclear receptor coactivator 4; cDNA FLJ59491, highly similar to Nuclear receptor coactivator 4 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Show all		514 aa 58.3 kDa	No	0
NCOA4-004 ENSP00000462352 ENST00000580070	B4DZ85 [Direct mapping] Nuclear receptor coactivator 4; cDNA FLJ58555, highly similar to Nuclear receptor coactivator 4 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Show all		448 aa 50.7 kDa	No	0
NCOA4-005 ENSP00000464054 ENST00000585132	Q13772 [Direct mapping] Nuclear receptor coactivator 4 A0A024QZI5 [Target identity:100%; Query identity:100%] Nuclear receptor coactivator 4, isoform CRA_a Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0003713 [transcription coactivator activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0008584 [male gonad development] GO:0030521 [androgen receptor signaling pathway] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0050681 [androgen receptor binding] Show all	614 aa 69.7 kDa	No	0
NCOA4-006 ENSP00000463476 ENST00000583565	Q13772 [Direct mapping] Nuclear receptor coactivator 4 A0A024QZI5 [Target identity:100%; Query identity:100%] Nuclear receptor coactivator 4, isoform CRA_a Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0003713 [transcription coactivator activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0008584 [male gonad development] GO:0030521 [androgen receptor signaling pathway] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0050681 [androgen receptor binding] Show all	614 aa 69.7 kDa	No	0
NCOA4-201 ENSP00000462943 ENST00000581486	Q13772 [Direct mapping] Nuclear receptor coactivator 4 A0A024QZI5 [Target identity:100%; Query identity:100%] Nuclear receptor coactivator 4, isoform CRA_a Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0003713 [transcription coactivator activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0008584 [male gonad development] GO:0030521 [androgen receptor signaling pathway] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0050681 [androgen receptor binding] Show all	614 aa 69.7 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.