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FXYD1

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GENERAL INFORMATION

Gene name

 FXYD1

Gene description

 FXYD domain containing ion transport regulator 1

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 8
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleus & cytosol. In addition localized to the nucleoli.

RNA cell category

 Cell line enhanced (ASC TERT1, WM-115)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (approved), Cytosol (approved)

Additional location

 In addition localized to the Nucleoli (approved)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA026873
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (ASC TERT1, WM-115)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleus & cytosol. In addition localized to the nucleoli.

Main location

 Nucleus (approved), Cytosol (approved)

Additional location

 Nucleoli (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA026873 A-431 Nucleus
Cytosol
HPA026873 BJ Nucleus
Nucleoli Intensity
HPA026873 U-2 OS Nucleus
Cytosol

GENE INFORMATION

Gene name

 FXYD1 (HGNC Symbol)

Synonyms

 PLM

Description

 FXYD domain containing ion transport regulator 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The protein encoded by this gene is a plasma membrane substrate for several kinases, including protein kinase A, protein kinase C, NIMA kinase, and myotonic dystrophy kinase. It is thought to form an ion channel or regulate ion channel activity. Transcript variants with different 5' UTR sequences have been described in the literature. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 q13.12

Chromosome location (bp)

 35138808 - 35143109

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000266964 (version 83.38)

Entrez gene

 5348

UniProt

 O00168 (UniProt - Evidence at protein level)

neXtProt

 NX_O00168

Antibodypedia

 FXYD1 antibodies

PROTEIN BROWSER
FXYD1-001
FXYD1-002
FXYD1-003
FXYD1-005
FXYD1-006
FXYD1-007
FXYD1-009
FXYD1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FXYD1-001
ENSP00000343314
ENST00000351325
O00168 [Direct mapping]
Phospholemman
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005254 [chloride channel activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005890 [sodium:potassium-exchanging ATPase complex]
GO:0006811 [ion transport]
GO:0006821 [chloride transport]
GO:0006936 [muscle contraction]
GO:0008016 [regulation of heart contraction]
GO:0016020 [membrane]
GO:0017080 [sodium channel regulator activity]
GO:0034220 [ion transmembrane transport]
GO:0034707 [chloride channel complex]
GO:0042383 [sarcolemma]
GO:0044325 [ion channel binding]
GO:0055085 [transmembrane transport]
GO:0086036 [regulation of cardiac muscle cell membrane potential]
GO:1902476 [chloride transmembrane transport]
GO:1903278 [positive regulation of sodium ion export from cell]
GO:2000649 [regulation of sodium ion transmembrane transporter activity]
Show all
 92 aa
10.4 kDa 		Yes 1
FXYD1-002
ENSP00000465289
ENST00000588715
O00168 [Direct mapping]
Phospholemman
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005254 [chloride channel activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005890 [sodium:potassium-exchanging ATPase complex]
GO:0006811 [ion transport]
GO:0006821 [chloride transport]
GO:0006936 [muscle contraction]
GO:0008016 [regulation of heart contraction]
GO:0016020 [membrane]
GO:0017080 [sodium channel regulator activity]
GO:0034220 [ion transmembrane transport]
GO:0034707 [chloride channel complex]
GO:0042383 [sarcolemma]
GO:0044325 [ion channel binding]
GO:0055085 [transmembrane transport]
GO:0086036 [regulation of cardiac muscle cell membrane potential]
GO:1902476 [chloride transmembrane transport]
GO:1903278 [positive regulation of sodium ion export from cell]
GO:2000649 [regulation of sodium ion transmembrane transporter activity]
Show all
 92 aa
10.4 kDa 		Yes 1
FXYD1-003
ENSP00000468535
ENST00000588607
O00168 [Direct mapping]
Phospholemman
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005254 [chloride channel activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005890 [sodium:potassium-exchanging ATPase complex]
GO:0006811 [ion transport]
GO:0006821 [chloride transport]
GO:0006936 [muscle contraction]
GO:0008016 [regulation of heart contraction]
GO:0016020 [membrane]
GO:0017080 [sodium channel regulator activity]
GO:0034220 [ion transmembrane transport]
GO:0034707 [chloride channel complex]
GO:0042383 [sarcolemma]
GO:0044325 [ion channel binding]
GO:0055085 [transmembrane transport]
GO:0086036 [regulation of cardiac muscle cell membrane potential]
GO:1902476 [chloride transmembrane transport]
GO:1903278 [positive regulation of sodium ion export from cell]
GO:2000649 [regulation of sodium ion transmembrane transporter activity]
Show all
 92 aa
10.4 kDa 		Yes 1
FXYD1-005
ENSP00000466398
ENST00000589209
O00168 [Direct mapping]
Phospholemman
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005254 [chloride channel activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005890 [sodium:potassium-exchanging ATPase complex]
GO:0006811 [ion transport]
GO:0006821 [chloride transport]
GO:0006936 [muscle contraction]
GO:0008016 [regulation of heart contraction]
GO:0016020 [membrane]
GO:0017080 [sodium channel regulator activity]
GO:0034220 [ion transmembrane transport]
GO:0034707 [chloride channel complex]
GO:0042383 [sarcolemma]
GO:0044325 [ion channel binding]
GO:0055085 [transmembrane transport]
GO:0086036 [regulation of cardiac muscle cell membrane potential]
GO:1902476 [chloride transmembrane transport]
GO:1903278 [positive regulation of sodium ion export from cell]
GO:2000649 [regulation of sodium ion transmembrane transporter activity]
Show all
 92 aa
10.4 kDa 		Yes 1
FXYD1-006
ENSP00000393611
ENST00000455515
O00168 [Direct mapping]
Phospholemman
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005254 [chloride channel activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005890 [sodium:potassium-exchanging ATPase complex]
GO:0006811 [ion transport]
GO:0006821 [chloride transport]
GO:0006936 [muscle contraction]
GO:0008016 [regulation of heart contraction]
GO:0016020 [membrane]
GO:0017080 [sodium channel regulator activity]
GO:0034220 [ion transmembrane transport]
GO:0034707 [chloride channel complex]
GO:0042383 [sarcolemma]
GO:0044325 [ion channel binding]
GO:0055085 [transmembrane transport]
GO:0086036 [regulation of cardiac muscle cell membrane potential]
GO:1902476 [chloride transmembrane transport]
GO:1903278 [positive regulation of sodium ion export from cell]
GO:2000649 [regulation of sodium ion transmembrane transporter activity]
Show all
 92 aa
10.4 kDa 		Yes 1
FXYD1-007
ENSP00000467727
ENST00000588081
O00168 [Direct mapping]
Phospholemman
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005254 [chloride channel activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005890 [sodium:potassium-exchanging ATPase complex]
GO:0006811 [ion transport]
GO:0006821 [chloride transport]
GO:0006936 [muscle contraction]
GO:0008016 [regulation of heart contraction]
GO:0016020 [membrane]
GO:0017080 [sodium channel regulator activity]
GO:0034220 [ion transmembrane transport]
GO:0034707 [chloride channel complex]
GO:0042383 [sarcolemma]
GO:0044325 [ion channel binding]
GO:0055085 [transmembrane transport]
GO:0086036 [regulation of cardiac muscle cell membrane potential]
GO:1902476 [chloride transmembrane transport]
GO:1903278 [positive regulation of sodium ion export from cell]
GO:2000649 [regulation of sodium ion transmembrane transporter activity]
Show all
 92 aa
10.4 kDa 		Yes 1
FXYD1-009
ENSP00000467818
ENST00000589121
K7EQG4 [Direct mapping]
Phospholemman
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0016020 [membrane]
GO:0017080 [sodium channel regulator activity]
GO:0034220 [ion transmembrane transport]
GO:2000649 [regulation of sodium ion transmembrane transporter activity]
Show all
 115 aa
12.8 kDa 		No 1
FXYD1-201
ENSP00000481244
ENST00000612146
O00168 [Direct mapping]
Phospholemman
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005254 [chloride channel activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005890 [sodium:potassium-exchanging ATPase complex]
GO:0006811 [ion transport]
GO:0006821 [chloride transport]
GO:0006936 [muscle contraction]
GO:0008016 [regulation of heart contraction]
GO:0016020 [membrane]
GO:0017080 [sodium channel regulator activity]
GO:0034220 [ion transmembrane transport]
GO:0034707 [chloride channel complex]
GO:0042383 [sarcolemma]
GO:0044325 [ion channel binding]
GO:0055085 [transmembrane transport]
GO:0086036 [regulation of cardiac muscle cell membrane potential]
GO:1902476 [chloride transmembrane transport]
GO:1903278 [positive regulation of sodium ion export from cell]
GO:2000649 [regulation of sodium ion transmembrane transporter activity]
Show all
 92 aa
10.4 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.