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SSX2B

GENERAL INFORMATION

Gene name

 SSX2B

Gene description

 Synovial sarcoma, X breakpoint 2B

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (testis)

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in testis.

DATA RELIABILITY

Data reliability
description

 Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded. Pending external verification.

Reliability score

 Supported based on 1 antibody.
HPA045683
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)

GENE INFORMATION

Gene name

 SSX2B (HGNC Symbol)

Synonyms

 CT5.2b

Description

 Synovial sarcoma, X breakpoint 2B (HGNC Symbol)

Entrez gene summary

 The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. This gene, and also the SSX1 and SSX4 family members, have been involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are likely responsible for transforming activity. Alternative splicing of this gene results in multiple transcript variants. This gene also has an identical duplicate, GeneID: 6757, located about 45 kb upstream in the opposite orientation on chromosome X. [provided by RefSeq, Jul 2013]

Chromosome

 X

Cytoband

 p11.22

Chromosome location (bp)

 52751132 - 52790305

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000268447 (version 83.38)

Entrez gene

 727837

UniProt

 Q16385 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16385

Antibodypedia

 SSX2B antibodies

PROTEIN BROWSER
SSX2B-001
SSX2B-002
SSX2B-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SSX2B-001
ENSP00000477922
ENST00000612490
Q16385 [Direct mapping]
Protein SSX2
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Show all
GO:0003676 [nucleic acid binding]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:1903507 [negative regulation of nucleic acid-templated transcription]
Show all
 223 aa
25.2 kDa 		No 0
SSX2B-002
ENSP00000470740
ENST00000596480
Q16385 [Direct mapping]
Protein SSX2
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Show all
GO:0003676 [nucleic acid binding]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:1903507 [negative regulation of nucleic acid-templated transcription]
Show all
 188 aa
21.6 kDa 		No 0
SSX2B-201
ENSP00000478714
ENST00000616191
Q16385 [Direct mapping]
Protein SSX2
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Show all
GO:0003676 [nucleic acid binding]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:1903507 [negative regulation of nucleic acid-templated transcription]
Show all
 188 aa
21.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.