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MAGEA2

GENERAL INFORMATION

Gene name

 MAGEA2

Gene description

 Melanoma antigen family A2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Not detected
HPA (cell line):Cell line enhanced (HMC-1, K-562, SH-SY5Y, U-266/70, U-266/84)
HPA (normal tissue):Tissue enriched (testis)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 MAGEA2 (HGNC Symbol)

Synonyms

 CT1.2, MAGE2, MAGEA2A

Description

 Melanoma antigen family A2 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. This gene has two identical copies at different loci. Alternatively spliced transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 X

Cytoband

 q28

Chromosome location (bp)

 152749863 - 152753884

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000268606 (version 83.38)

Entrez gene

 4101

UniProt

 P43356 (UniProt - Evidence at protein level)

neXtProt

 NX_P43356

Antibodypedia

 MAGEA2 antibodies

PROTEIN BROWSER
MAGEA2-001
MAGEA2-002
MAGEA2-003
MAGEA2-004
MAGEA2-201
MAGEA2-202
MAGEA2-203
MAGEA2-204
MAGEA2-205

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MAGEA2-001
ENSP00000484290
ENST00000620710
P43356 [Direct mapping]
Melanoma-associated antigen 2
A0A024RC17 [Target identity:100%; Query identity:100%]
HCG1739882, isoform CRA_a
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0016605 [PML body]
GO:0031625 [ubiquitin protein ligase binding]
GO:0033234 [negative regulation of protein sumoylation]
GO:0042826 [histone deacetylase binding]
GO:0044257 [cellular protein catabolic process]
GO:0051443 [positive regulation of ubiquitin-protein transferase activity]
GO:0070491 [repressing transcription factor binding]
GO:0072331 [signal transduction by p53 class mediator]
GO:0090398 [cellular senescence]
GO:1901984 [negative regulation of protein acetylation]
Show all
 314 aa
35.1 kDa 		No 0
MAGEA2-002
ENSP00000470872
ENST00000595583
P43356 [Direct mapping]
Melanoma-associated antigen 2
A0A024RC17 [Target identity:100%; Query identity:100%]
HCG1739882, isoform CRA_a
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0016605 [PML body]
GO:0031625 [ubiquitin protein ligase binding]
GO:0033234 [negative regulation of protein sumoylation]
GO:0042826 [histone deacetylase binding]
GO:0044257 [cellular protein catabolic process]
GO:0051443 [positive regulation of ubiquitin-protein transferase activity]
GO:0070491 [repressing transcription factor binding]
GO:0072331 [signal transduction by p53 class mediator]
GO:0090398 [cellular senescence]
GO:1901984 [negative regulation of protein acetylation]
Show all
 314 aa
35.1 kDa 		No 0
MAGEA2-003
ENSP00000482879
ENST00000617846
A0A087WZT8 [Direct mapping]
Melanoma-associated antigen 2
Show all
Predicted intracellular proteins
Show all
 80 aa
8.4 kDa 		No 0
MAGEA2-004
ENSP00000483352
ENST00000617505
E7ENJ0 [Direct mapping]
Melanoma-associated antigen 2
Show all
Predicted intracellular proteins
Show all
 37 aa
4 kDa 		No 0
MAGEA2-201
ENSP00000469919
ENST00000598543
P43356 [Direct mapping]
Melanoma-associated antigen 2
A0A024RC17 [Target identity:100%; Query identity:100%]
HCG1739882, isoform CRA_a
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0016605 [PML body]
GO:0031625 [ubiquitin protein ligase binding]
GO:0033234 [negative regulation of protein sumoylation]
GO:0042826 [histone deacetylase binding]
GO:0044257 [cellular protein catabolic process]
GO:0051443 [positive regulation of ubiquitin-protein transferase activity]
GO:0070491 [repressing transcription factor binding]
GO:0072331 [signal transduction by p53 class mediator]
GO:0090398 [cellular senescence]
GO:1901984 [negative regulation of protein acetylation]
Show all
 314 aa
35.1 kDa 		No 0
MAGEA2-202
ENSP00000480738
ENST00000611557
P43356 [Direct mapping]
Melanoma-associated antigen 2
A0A024RC17 [Target identity:100%; Query identity:100%]
HCG1739882, isoform CRA_a
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0016605 [PML body]
GO:0031625 [ubiquitin protein ligase binding]
GO:0033234 [negative regulation of protein sumoylation]
GO:0042826 [histone deacetylase binding]
GO:0044257 [cellular protein catabolic process]
GO:0051443 [positive regulation of ubiquitin-protein transferase activity]
GO:0070491 [repressing transcription factor binding]
GO:0072331 [signal transduction by p53 class mediator]
GO:0090398 [cellular senescence]
GO:1901984 [negative regulation of protein acetylation]
Show all
 314 aa
35.1 kDa 		No 0
MAGEA2-203
ENSP00000480491
ENST00000611674
P43356 [Direct mapping]
Melanoma-associated antigen 2
A0A024RC17 [Target identity:100%; Query identity:100%]
HCG1739882, isoform CRA_a
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0016605 [PML body]
GO:0031625 [ubiquitin protein ligase binding]
GO:0033234 [negative regulation of protein sumoylation]
GO:0042826 [histone deacetylase binding]
GO:0044257 [cellular protein catabolic process]
GO:0051443 [positive regulation of ubiquitin-protein transferase activity]
GO:0070491 [repressing transcription factor binding]
GO:0072331 [signal transduction by p53 class mediator]
GO:0090398 [cellular senescence]
GO:1901984 [negative regulation of protein acetylation]
Show all
 314 aa
35.1 kDa 		No 0
MAGEA2-204
ENSP00000485391
ENST00000623438
P43356 [Direct mapping]
Melanoma-associated antigen 2
A0A024RC17 [Target identity:100%; Query identity:100%]
HCG1739882, isoform CRA_a
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0016605 [PML body]
GO:0031625 [ubiquitin protein ligase binding]
GO:0033234 [negative regulation of protein sumoylation]
GO:0042826 [histone deacetylase binding]
GO:0044257 [cellular protein catabolic process]
GO:0051443 [positive regulation of ubiquitin-protein transferase activity]
GO:0070491 [repressing transcription factor binding]
GO:0072331 [signal transduction by p53 class mediator]
GO:0090398 [cellular senescence]
GO:1901984 [negative regulation of protein acetylation]
Show all
 314 aa
35.1 kDa 		No 0
MAGEA2-205
ENSP00000485541
ENST00000623806
P43356 [Direct mapping]
Melanoma-associated antigen 2
A0A024RC17 [Target identity:100%; Query identity:100%]
HCG1739882, isoform CRA_a
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0016605 [PML body]
GO:0031625 [ubiquitin protein ligase binding]
GO:0033234 [negative regulation of protein sumoylation]
GO:0042826 [histone deacetylase binding]
GO:0044257 [cellular protein catabolic process]
GO:0051443 [positive regulation of ubiquitin-protein transferase activity]
GO:0070491 [repressing transcription factor binding]
GO:0072331 [signal transduction by p53 class mediator]
GO:0090398 [cellular senescence]
GO:1901984 [negative regulation of protein acetylation]
Show all
 314 aa
35.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.