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IKBKG

GENERAL INFORMATION

Gene name

 IKBKG

Gene description

 Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma

Protein class

 Disease related genes
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 13
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Uncertain based on 2 antibodies.
HPA000426 , CAB010373
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA000426
CAB010373

GENE INFORMATION

Gene name

 IKBKG (HGNC Symbol)

Synonyms

 FIP-3, FIP3, Fip3p, IKK-gamma, IP1, IP2, NEMO, ZC2HC9

Description

 Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma (HGNC Symbol)

Entrez gene summary

 This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome. [provided by RefSeq, Aug 2011]

Chromosome

 X

Cytoband

 q28

Chromosome location (bp)

 154541199 - 154565046

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000269335 (version 83.38)

Entrez gene

 8517

UniProt

 Q9Y6K9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y6K9

Antibodypedia

 IKBKG antibodies

PROTEIN BROWSER
«
IKBKG-002
IKBKG-004
IKBKG-005
IKBKG-006
IKBKG-007
IKBKG-008
IKBKG-009
IKBKG-010
IKBKG-012
IKBKG-013
IKBKG-014
IKBKG-016
IKBKG-017
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IKBKG-002
ENSP00000483825
ENST00000618670
Q9Y6K9 [Direct mapping]
NF-kappa-B essential modulator
Show all
Predicted intracellular proteins
RAS pathway related proteins
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0000187 [activation of MAPK activity]
GO:0000922 [spindle pole]
GO:0001782 [B cell homeostasis]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0007250 [activation of NF-kappaB-inducing kinase activity]
GO:0007254 [JNK cascade]
GO:0008385 [IkappaB kinase complex]
GO:0009615 [response to virus]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0016032 [viral process]
GO:0019904 [protein domain specific binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032481 [positive regulation of type I interferon production]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042803 [protein homodimerization activity]
GO:0042975 [peroxisome proliferator activated receptor binding]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
GO:0050852 [T cell receptor signaling pathway]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
GO:0051650 [establishment of vesicle localization]
GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]
GO:0070530 [K63-linked polyubiquitin binding]
GO:0072686 [mitotic spindle]
GO:1901215 [negative regulation of neuron death]
GO:1990450 [linear polyubiquitin binding]
Show all
 487 aa
55.8 kDa 		No 0
IKBKG-004
ENSP00000471166
ENST00000594239
Q9Y6K9 [Direct mapping]
NF-kappa-B essential modulator
Show all
Predicted intracellular proteins
RAS pathway related proteins
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0000187 [activation of MAPK activity]
GO:0000922 [spindle pole]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0007254 [JNK cascade]
GO:0008385 [IkappaB kinase complex]
GO:0009615 [response to virus]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0016032 [viral process]
GO:0019904 [protein domain specific binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032481 [positive regulation of type I interferon production]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042803 [protein homodimerization activity]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
GO:0050852 [T cell receptor signaling pathway]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
GO:0051650 [establishment of vesicle localization]
GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]
GO:0072686 [mitotic spindle]
GO:1901215 [negative regulation of neuron death]
GO:1990450 [linear polyubiquitin binding]
Show all
 419 aa
48.2 kDa 		No 0
IKBKG-005
ENSP00000479662
ENST00000611071
Q9Y6K9 [Direct mapping]
NF-kappa-B essential modulator
Show all
Predicted intracellular proteins
RAS pathway related proteins
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0000187 [activation of MAPK activity]
GO:0000922 [spindle pole]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0007254 [JNK cascade]
GO:0008385 [IkappaB kinase complex]
GO:0009615 [response to virus]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0016032 [viral process]
GO:0019904 [protein domain specific binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032481 [positive regulation of type I interferon production]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042803 [protein homodimerization activity]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
GO:0050852 [T cell receptor signaling pathway]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
GO:0051650 [establishment of vesicle localization]
GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]
GO:0072686 [mitotic spindle]
GO:1901215 [negative regulation of neuron death]
GO:1990450 [linear polyubiquitin binding]
Show all
 419 aa
48.2 kDa 		No 0
IKBKG-006
ENSP00000478616
ENST00000611176
Q9Y6K9 [Direct mapping]
NF-kappa-B essential modulator
Show all
Predicted intracellular proteins
RAS pathway related proteins
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0000187 [activation of MAPK activity]
GO:0000922 [spindle pole]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0007254 [JNK cascade]
GO:0008385 [IkappaB kinase complex]
GO:0009615 [response to virus]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0016032 [viral process]
GO:0019904 [protein domain specific binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032481 [positive regulation of type I interferon production]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042803 [protein homodimerization activity]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
GO:0050852 [T cell receptor signaling pathway]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
GO:0051650 [establishment of vesicle localization]
GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]
GO:0072686 [mitotic spindle]
GO:1901215 [negative regulation of neuron death]
GO:1990450 [linear polyubiquitin binding]
Show all
 320 aa
37 kDa 		No 0
IKBKG-007
ENSP00000394934
ENST00000440286
C9JN51 [Direct mapping]
NF-kappa-B essential modulator
Show all
Predicted intracellular proteins
RAS pathway related proteins
Show all
GO:0005737 [cytoplasm]
Show all
 251 aa
28.8 kDa 		No 0
IKBKG-008
ENSP00000390368
ENST00000422680
C9JH59 [Direct mapping]
NF-kappa-B essential modulator
Show all
Predicted intracellular proteins
RAS pathway related proteins
Show all
GO:0005737 [cytoplasm]
Show all
 173 aa
19.9 kDa 		No 0
IKBKG-009
ENSP00000398579
ENST00000413620
C9J2V2 [Direct mapping]
NF-kappa-B essential modulator
Show all
Predicted intracellular proteins
RAS pathway related proteins
Show all
GO:0005737 [cytoplasm]
Show all
 195 aa
22.3 kDa 		No 0
IKBKG-010
ENSP00000484275
ENST00000492469
A0A087X1K7 [Direct mapping]
NF-kappa-B essential modulator
Show all
Predicted intracellular proteins
RAS pathway related proteins
Show all
 181 aa
20.6 kDa 		No 0
IKBKG-012
ENSP00000395205
ENST00000445622
C9JCG6 [Direct mapping]
NF-kappa-B essential modulator
Show all
Predicted intracellular proteins
RAS pathway related proteins
Show all
GO:0005737 [cytoplasm]
Show all
 138 aa
16.1 kDa 		No 0
IKBKG-013
ENSP00000479144
ENST00000615186
A0A087WV30 [Direct mapping]
NF-kappa-B essential modulator
Show all
Predicted intracellular proteins
RAS pathway related proteins
Show all
 115 aa
13 kDa 		No 0
IKBKG-014
ENSP00000478979
ENST00000619941
A0A087WUW6 [Direct mapping]
NF-kappa-B essential modulator
Show all
Predicted intracellular proteins
RAS pathway related proteins
Show all
 412 aa
47.4 kDa 		No 0
IKBKG-016
ENSP00000483381
ENST00000615874
A0A087X0G7 [Direct mapping]
NF-kappa-B essential modulator
Show all
Predicted intracellular proteins
RAS pathway related proteins
Show all
 411 aa
47.3 kDa 		No 0
IKBKG-017
ENSP00000484023
ENST00000617207
A0A087X1B1 [Direct mapping]
NF-kappa-B essential modulator
Show all
Predicted intracellular proteins
RAS pathway related proteins
Show all
 418 aa
48.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.