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SSX4B

GENERAL INFORMATION

Gene name

 SSX4B

Gene description

 Synovial sarcoma, X breakpoint 4B

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (testis)

Protein evidence

 Evidence at transcript level

Protein expression

 Nuclear expression in testis.

DATA RELIABILITY

Data reliability
description

 Pending external verification. Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA045683
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)

GENE INFORMATION

Gene name

 SSX4B (HGNC Symbol)

Synonyms

 OTTHUMT00000056510

Description

 Synovial sarcoma, X breakpoint 4B (HGNC Symbol)

Entrez gene summary

 The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. Chromosome Xp11 contains a segmental duplication resulting in two identical copies of synovial sarcoma, X breakpoint 4, SSX4 and SSX4B, in tail-to-tail orientation. This gene, SSX4B, represents the more centromeric copy. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 X

Cytoband

 p11.23

Chromosome location (bp)

 48402078 - 48411910

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000269791 (version 83.38)

Entrez gene

 548313

UniProt

 O60224 (UniProt - Evidence at transcript level)

neXtProt

 NX_O60224

Antibodypedia

 SSX4B antibodies

PROTEIN BROWSER
SSX4B-001
SSX4B-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SSX4B-001
ENSP00000469394
ENST00000595235
O60224 [Direct mapping]
Protein SSX4
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Predicted intracellular proteins
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GO:0003676 [nucleic acid binding]
GO:0003714 [transcription corepressor activity]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:1903507 [negative regulation of nucleic acid-templated transcription]
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 188 aa
21.9 kDa 		No 0
SSX4B-201
ENSP00000481765
ENST00000619890
O60224 [Direct mapping]
Protein SSX4
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Predicted intracellular proteins
Show all
GO:0003676 [nucleic acid binding]
GO:0003714 [transcription corepressor activity]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:1903507 [negative regulation of nucleic acid-templated transcription]
Show all
 153 aa
17.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.