Expression of TAF15 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

TAF15

premium

TISSUE

premium

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TAF15
Gene description	TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
Protein class	Cancer-related genes Disease related genes Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	7
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA052059
	SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA052059

GENE INFORMATION
Gene name	TAF15 (HGNC Symbol)
Synonyms	hTAFII68, Npl3, RBP56, TAF2N
Description	TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the TET family of RNA-binding proteins. The encoded protein plays a role in RNA polymerase II gene transcription as a component of a distinct subset of multi-subunit transcription initiation factor TFIID complexes. Translocations involving this gene play a role in acute leukemia and extraskeletal myxoid chondrosarcoma, and mutations in this gene may play a role in amyotrophic lateral sclerosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
Chromosome	17
Cytoband	q12
Chromosome location (bp)	35713791 - 35864615
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000270647 (version 83.38)
Entrez gene	8148
UniProt	Q92804 (UniProt - Evidence at protein level)
neXtProt	NX_Q92804
Antibodypedia	TAF15 antibodies

PROTEIN BROWSER

TAF15-001	TAF15-004	TAF15-006	TAF15-007	TAF15-009	TAF15-014	TAF15-015

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TAF15-001 ENSP00000474096 ENST00000605844	Q92804 [Direct mapping] TATA-binding protein-associated factor 2N Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0008270 [zinc ion binding] GO:0044822 [poly(A) RNA binding] GO:0045893 [positive regulation of transcription, DNA-templated] Show all	592 aa 61.8 kDa	No	0
TAF15-004 ENSP00000474609 ENST00000604841	Q92804 [Direct mapping] TATA-binding protein-associated factor 2N Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0008270 [zinc ion binding] GO:0044822 [poly(A) RNA binding] GO:0045893 [positive regulation of transcription, DNA-templated] Show all	589 aa 61.6 kDa	No	0
TAF15-006 ENSP00000474522 ENST00000603777	A0A075B7D9 [Direct mapping] TATA-binding protein-associated factor 2N Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0008270 [zinc ion binding] Show all	449 aa 48.8 kDa	No	1
TAF15-007 ENSP00000475044 ENST00000604879	A0A075B7F2 [Direct mapping] TATA-binding protein-associated factor 2N Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Show all		239 aa 26.2 kDa	No	0
TAF15-009 ENSP00000474436 ENST00000603427	A0A075B7D6 [Direct mapping] TATA-binding protein-associated factor 2N Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Show all		32 aa 3.5 kDa	No	0
TAF15-014 ENSP00000475147 ENST00000604694	A0A075B7F4 [Direct mapping] TATA-binding protein-associated factor 2N Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Show all	GO:0008270 [zinc ion binding] Show all	214 aa 21.2 kDa	No	0
TAF15-015 ENSP00000474047 ENST00000603967	A0A075B7C1 [Direct mapping] TATA-binding protein-associated factor 2N Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Show all		102 aa 10.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.