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CCL5

GENERAL INFORMATION

Gene name

 CCL5

Gene description

 Chemokine (C-C motif) ligand 5

Protein class

 Cancer-related genes
Plasma proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Membrane,Secreted

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (spleen)
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (spleen)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CCL5 (HGNC Symbol)

Synonyms

 D17S136E, MGC17164, RANTES, SCYA5, SISd, TCP228

Description

 Chemokine (C-C motif) ligand 5 (HGNC Symbol)

Entrez gene summary

 This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]

Chromosome

 17

Cytoband

 q12

Chromosome location (bp)

 35871491 - 35880793

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000271503 (version 83.38)

Entrez gene

 6352

UniProt

 P13501 (UniProt - Evidence at protein level)

neXtProt

 NX_P13501

Antibodypedia

 CCL5 antibodies

PROTEIN BROWSER
CCL5-001
CCL5-002
CCL5-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CCL5-001
ENSP00000474412
ENST00000603197
P13501 [Direct mapping]
C-C motif chemokine 5 RANTES(3-68) RANTES(4-68)
D0EI67 [Target identity:100%; Query identity:100%]
C-C motif chemokine
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0002407 [dendritic cell chemotaxis]
GO:0002544 [chronic inflammatory response]
GO:0002548 [monocyte chemotaxis]
GO:0002676 [regulation of chronic inflammatory response]
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0004672 [protein kinase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0006816 [calcium ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0006887 [exocytosis]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007159 [leukocyte cell-cell adhesion]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007568 [aging]
GO:0008009 [chemokine activity]
GO:0008201 [heparin binding]
GO:0009615 [response to virus]
GO:0009617 [response to bacterium]
GO:0009636 [response to toxic substance]
GO:0009651 [response to salt stress]
GO:0010535 [positive regulation of activation of JAK2 kinase activity]
GO:0010628 [positive regulation of gene expression]
GO:0010759 [positive regulation of macrophage chemotaxis]
GO:0010820 [positive regulation of T cell chemotaxis]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0014070 [response to organic cyclic compound]
GO:0014823 [response to activity]
GO:0014911 [positive regulation of smooth muscle cell migration]
GO:0016004 [phospholipase activator activity]
GO:0018894 [dibenzo-p-dioxin metabolic process]
GO:0030298 [receptor signaling protein tyrosine kinase activator activity]
GO:0030335 [positive regulation of cell migration]
GO:0030593 [neutrophil chemotaxis]
GO:0031328 [positive regulation of cellular biosynthetic process]
GO:0031584 [activation of phospholipase D activity]
GO:0031622 [positive regulation of fever generation]
GO:0031663 [lipopolysaccharide-mediated signaling pathway]
GO:0031667 [response to nutrient levels]
GO:0031726 [CCR1 chemokine receptor binding]
GO:0031729 [CCR4 chemokine receptor binding]
GO:0031730 [CCR5 chemokine receptor binding]
GO:0032496 [response to lipopolysaccharide]
GO:0032868 [response to insulin]
GO:0033634 [positive regulation of cell-cell adhesion mediated by integrin]
GO:0034097 [response to cytokine]
GO:0034112 [positive regulation of homotypic cell-cell adhesion]
GO:0034612 [response to tumor necrosis factor]
GO:0042056 [chemoattractant activity]
GO:0042102 [positive regulation of T cell proliferation]
GO:0042119 [neutrophil activation]
GO:0042327 [positive regulation of phosphorylation]
GO:0042379 [chemokine receptor binding]
GO:0042493 [response to drug]
GO:0042531 [positive regulation of tyrosine phosphorylation of STAT protein]
GO:0042803 [protein homodimerization activity]
GO:0043491 [protein kinase B signaling]
GO:0043547 [positive regulation of GTPase activity]
GO:0043621 [protein self-association]
GO:0043623 [cellular protein complex assembly]
GO:0043627 [response to estrogen]
GO:0043922 [negative regulation by host of viral transcription]
GO:0044344 [cellular response to fibroblast growth factor stimulus]
GO:0045070 [positive regulation of viral genome replication]
GO:0045071 [negative regulation of viral genome replication]
GO:0045089 [positive regulation of innate immune response]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045672 [positive regulation of osteoclast differentiation]
GO:0045744 [negative regulation of G-protein coupled receptor protein signaling pathway]
GO:0045766 [positive regulation of angiogenesis]
GO:0045785 [positive regulation of cell adhesion]
GO:0045948 [positive regulation of translational initiation]
GO:0046427 [positive regulation of JAK-STAT cascade]
GO:0046817 [chemokine receptor antagonist activity]
GO:0048245 [eosinophil chemotaxis]
GO:0048246 [macrophage chemotaxis]
GO:0048247 [lymphocyte chemotaxis]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050729 [positive regulation of inflammatory response]
GO:0050796 [regulation of insulin secretion]
GO:0050863 [regulation of T cell activation]
GO:0050918 [positive chemotaxis]
GO:0051262 [protein tetramerization]
GO:0051384 [response to glucocorticoid]
GO:0051928 [positive regulation of calcium ion transport]
GO:0060548 [negative regulation of cell death]
GO:0060754 [positive regulation of mast cell chemotaxis]
GO:0061098 [positive regulation of protein tyrosine kinase activity]
GO:0070098 [chemokine-mediated signaling pathway]
GO:0070100 [negative regulation of chemokine-mediated signaling pathway]
GO:0070233 [negative regulation of T cell apoptotic process]
GO:0070234 [positive regulation of T cell apoptotic process]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070723 [response to cholesterol]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071230 [cellular response to amino acid stimulus]
GO:0071307 [cellular response to vitamin K]
GO:0071315 [cellular response to morphine]
GO:0071345 [cellular response to cytokine stimulus]
GO:0071346 [cellular response to interferon-gamma]
GO:0071347 [cellular response to interleukin-1]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071361 [cellular response to ethanol]
GO:0071396 [cellular response to lipid]
GO:0071403 [cellular response to high density lipoprotein particle stimulus]
GO:0071407 [cellular response to organic cyclic compound]
GO:0071448 [cellular response to alkyl hydroperoxide]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:0090026 [positive regulation of monocyte chemotaxis]
GO:1901214 [regulation of neuron death]
GO:1901215 [negative regulation of neuron death]
GO:2000110 [negative regulation of macrophage apoptotic process]
GO:2000406 [positive regulation of T cell migration]
GO:2000503 [positive regulation of natural killer cell chemotaxis]
Show all
 91 aa
10 kDa 		Yes 0
CCL5-002
ENSP00000475057
ENST00000605140
P13501 [Direct mapping]
C-C motif chemokine 5 RANTES(3-68) RANTES(4-68)
D0EI67 [Target identity:100%; Query identity:100%]
C-C motif chemokine
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Show all
GO:0000165 [MAPK cascade]
GO:0002407 [dendritic cell chemotaxis]
GO:0002548 [monocyte chemotaxis]
GO:0002676 [regulation of chronic inflammatory response]
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0004672 [protein kinase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006816 [calcium ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0006887 [exocytosis]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007159 [leukocyte cell-cell adhesion]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0008009 [chemokine activity]
GO:0009615 [response to virus]
GO:0009636 [response to toxic substance]
GO:0010535 [positive regulation of activation of JAK2 kinase activity]
GO:0010759 [positive regulation of macrophage chemotaxis]
GO:0010820 [positive regulation of T cell chemotaxis]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0014911 [positive regulation of smooth muscle cell migration]
GO:0016004 [phospholipase activator activity]
GO:0030298 [receptor signaling protein tyrosine kinase activator activity]
GO:0030335 [positive regulation of cell migration]
GO:0030593 [neutrophil chemotaxis]
GO:0031328 [positive regulation of cellular biosynthetic process]
GO:0031584 [activation of phospholipase D activity]
GO:0031663 [lipopolysaccharide-mediated signaling pathway]
GO:0031726 [CCR1 chemokine receptor binding]
GO:0031729 [CCR4 chemokine receptor binding]
GO:0031730 [CCR5 chemokine receptor binding]
GO:0033634 [positive regulation of cell-cell adhesion mediated by integrin]
GO:0034112 [positive regulation of homotypic cell-cell adhesion]
GO:0042056 [chemoattractant activity]
GO:0042102 [positive regulation of T cell proliferation]
GO:0042119 [neutrophil activation]
GO:0042327 [positive regulation of phosphorylation]
GO:0042379 [chemokine receptor binding]
GO:0042531 [positive regulation of tyrosine phosphorylation of STAT protein]
GO:0042803 [protein homodimerization activity]
GO:0043491 [protein kinase B signaling]
GO:0043547 [positive regulation of GTPase activity]
GO:0043621 [protein self-association]
GO:0043623 [cellular protein complex assembly]
GO:0043922 [negative regulation by host of viral transcription]
GO:0044344 [cellular response to fibroblast growth factor stimulus]
GO:0045070 [positive regulation of viral genome replication]
GO:0045071 [negative regulation of viral genome replication]
GO:0045089 [positive regulation of innate immune response]
GO:0045744 [negative regulation of G-protein coupled receptor protein signaling pathway]
GO:0045785 [positive regulation of cell adhesion]
GO:0045948 [positive regulation of translational initiation]
GO:0046427 [positive regulation of JAK-STAT cascade]
GO:0046817 [chemokine receptor antagonist activity]
GO:0048245 [eosinophil chemotaxis]
GO:0048246 [macrophage chemotaxis]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0050729 [positive regulation of inflammatory response]
GO:0050796 [regulation of insulin secretion]
GO:0050863 [regulation of T cell activation]
GO:0050918 [positive chemotaxis]
GO:0051262 [protein tetramerization]
GO:0051928 [positive regulation of calcium ion transport]
GO:0061098 [positive regulation of protein tyrosine kinase activity]
GO:0070098 [chemokine-mediated signaling pathway]
GO:0070100 [negative regulation of chemokine-mediated signaling pathway]
GO:0070233 [negative regulation of T cell apoptotic process]
GO:0070234 [positive regulation of T cell apoptotic process]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071346 [cellular response to interferon-gamma]
GO:0071347 [cellular response to interleukin-1]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071407 [cellular response to organic cyclic compound]
GO:0090026 [positive regulation of monocyte chemotaxis]
GO:1901214 [regulation of neuron death]
GO:2000406 [positive regulation of T cell migration]
GO:2000503 [positive regulation of natural killer cell chemotaxis]
Show all
 91 aa
10 kDa 		Yes 0
CCL5-003
ENSP00000474141
ENST00000605509
A0A075B7C5 [Direct mapping]
C-C motif chemokine 5
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0008009 [chemokine activity]
GO:0009615 [response to virus]
GO:0031726 [CCR1 chemokine receptor binding]
GO:0031729 [CCR4 chemokine receptor binding]
GO:0031730 [CCR5 chemokine receptor binding]
GO:0060326 [cell chemotaxis]
GO:0070098 [chemokine-mediated signaling pathway]
Show all
 150 aa
16.5 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.