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DCP1A

GENERAL INFORMATION

Gene name

 DCP1A

Gene description

 Decapping mRNA 1A

Protein class

 Plasma proteins
Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several different tissue types.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA013202
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and colorectal cancer (favourable).
Liver cancer p<0.001
Colorectal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA013202

GENE INFORMATION

Gene name

 DCP1A (HGNC Symbol)

Synonyms

 HSA275986, SMAD4IP1, SMIF

Description

 Decapping mRNA 1A (HGNC Symbol)

Entrez gene summary

 Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Chromosome

 3

Cytoband

 p21.1

Chromosome location (bp)

 53283428 - 53347610

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000272886 (version 83.38)

Entrez gene

 55802

UniProt

 Q9NPI6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NPI6

Antibodypedia

 DCP1A antibodies

PROTEIN BROWSER
DCP1A-001
DCP1A-004
DCP1A-009
DCP1A-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DCP1A-001
ENSP00000476386
ENST00000610213
Q9NPI6 [Direct mapping]
mRNA-decapping enzyme 1A
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Transporters
   Primary Active Transporters
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
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GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016787 [hydrolase activity]
GO:0042802 [identical protein binding]
GO:0043488 [regulation of mRNA stability]
GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay]
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 582 aa
63.3 kDa 		No 0
DCP1A-004
ENSP00000476046
ENST00000294241
Q9NPI6 [Direct mapping]
mRNA-decapping enzyme 1A
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Transporters
   Primary Active Transporters
Predicted intracellular proteins
Plasma proteins
Show all
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016787 [hydrolase activity]
GO:0042802 [identical protein binding]
GO:0043488 [regulation of mRNA stability]
GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay]
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 544 aa
59.3 kDa 		No 0
DCP1A-009
ENSP00000477594
ENST00000560624
A0A087WT55 [Direct mapping]
mRNA-decapping enzyme 1A
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Predicted intracellular proteins
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 260 aa
29.1 kDa 		No 0
DCP1A-010
ENSP00000479387
ENST00000559748
A0A087WVE6 [Direct mapping]
mRNA-decapping enzyme 1A
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Predicted intracellular proteins
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 191 aa
21.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.