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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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NBPF26
  • TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

NBPF26

Gene description

Neuroblastoma breakpoint family, member 26

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

8
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Mixed
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Pending external verification. Caution, targets protein from more than one gene.

Reliability score

Uncertain based on 8 antibodies.
HPA038748 , HPA038752 , HPA042595 , HPA043105 , HPA043692 , HPA044023 , HPA046971 , HPA058050
SHOW MORE

PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY

HPA038748
HPA038752
HPA042595
HPA043105
HPA043692
HPA044023
HPA046971
HPA058050

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancer cells displayed weak to moderate cytoplasmic staining. Several colorectal cancers along with a few ovarian, stomach, liver and pancreatic cancers showed strong immunoreactivity. Several lymphomas, testis, renal and cervical cancers were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Rare case of glioma and breast cancer displayed strong cytoplasmic staining. Moderate positivity was observed in occasional cases of ovarian, cervical, endometrial and pancreatic cancers. Remaining cancer tissues were weakly stained or negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Occasional cases of melanomas, urothelial and thyroid cancers showed moderate cytoplasmic positivity. Remaining cancer tissues were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer tissues were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Several renal cancers exhibited moderate cytoplasmic, nuclear and membranous positivity. A few cases of hepatocellular and urothelial carcinomas showed moderate cytoplasmic and nuclear staining. Remaining cancer tissues were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Several cases of squamous cell carcinomas of lung, cervix, skin, papillary adenocarcinomas of thyroid, ovarian, colorectal and pancreatic cancers showed moderate to strong membranous staining. Remaining cancer tissues were weakly stained or negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

A single case of squamous cell carcinoma of head and neck cancer showed moderate nuclear immunoreactivity. Rare cases of endometrial, thyroid and pancreatic cancers exhibited weak nuclear staining. Remaining cancer tissues were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most liver cancers, lobular carcinomas of breast and adenocarcinomas of lung along with few stomach cancers showed moderate cytoplasmic immunoreactivity. Remaining cancer tissues were negative.

GENE INFORMATION

Gene name

NBPF26

Synonyms

Description

Neuroblastoma breakpoint family, member 26 (HGNC Symbol)

Entrez gene summary

Chromosome

1

Cytoband

p11.2

Chromosome location (bp)

120805418 - 120841481

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000273136 (version 83.38)

Entrez gene

101060684

UniProt

neXtProt

Antibodypedia

NBPF26 antibodies

PROTEIN BROWSER

NBPF26-001
NBPF26-201
NBPF26-202
NBPF26-203
NBPF26-204
NBPF26-205
NBPF26-206
NBPF26-207

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NBPF26-001
ENSP00000481542
ENST00000620612
A0A087WY62 [Direct mapping]
Neuroblastoma breakpoint family member 26
Show all
Predicted intracellular proteins
Show all
1186 aa
136.2 kDa
No 0
NBPF26-201
ENSP00000476257
ENST00000609741
A0A075B7F9 [Direct mapping]
Neuroblastoma breakpoint family member 26
Show all
Predicted intracellular proteins
Show all
921 aa
105.8 kDa
No 0
NBPF26-202
ENSP00000482859
ENST00000611287
A0A087WZS8 [Direct mapping]
Neuroblastoma breakpoint family member 26
Show all
Predicted intracellular proteins
Show all
867 aa
99.7 kDa
No 0
NBPF26-203
ENSP00000478334
ENST00000611702
A0A087WU30 [Direct mapping]
Neuroblastoma breakpoint family member 26
Show all
Predicted intracellular proteins
Show all
577 aa
66.8 kDa
No 0
NBPF26-204
ENSP00000477847
ENST00000615145
A0A087WTG0 [Direct mapping]
Neuroblastoma breakpoint family member 26
Show all
Predicted intracellular proteins
Show all
535 aa
60.4 kDa
No 0
NBPF26-205
ENSP00000479721
ENST00000615219
A0A087WVV8 [Direct mapping]
Neuroblastoma breakpoint family member 26
Show all
Predicted intracellular proteins
Show all
299 aa
33.9 kDa
No 0
NBPF26-206
ENSP00000480416
ENST00000617913
A0A087WWQ1 [Direct mapping]
Neuroblastoma breakpoint family member 26
Show all
Predicted intracellular proteins
Show all
942 aa
108.3 kDa
No 0
NBPF26-207
ENSP00000482516
ENST00000619748
A0A087WZB6 [Direct mapping]
Neuroblastoma breakpoint family member 26
Show all
Predicted intracellular proteins
Show all
602 aa
69.4 kDa
No 0

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The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.