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Antibody staining mainly consistent with RNA expression data. Pending external verification. Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded.
Several seminomas along with few ovarian, stomach and endometrial cancers showed moderate nuclear immunoreactivity. A single case of high grade urothelial cancer was strongly stained. Remaining cancer tissues were negative.
Occasional cases of urothelial, liver, lung, testicular and endometrial cancers showed moderate to strong cytoplasmic/nuclear positivity. Other malignant tissues were negative.
Few cases of squamous cell carcinomas of lung, seminomas and occasional urothelial malignancies showed moderate to strong nuclear positivity. Other malignant tissues were negative.
Seminomas of testis showed strong nuclear staining. A single case each of squamous cell carcinoma of lung and skin along with stomach and urothelial cancers displayed strong positivity. Remaining cancer tissues were weakly stained or negative.
GENE INFORMATION
Gene name
CT45A7
Synonyms
Description
Cancer/testis antigen family 45, member A7 (HGNC Symbol)