Expression of NOL12 in cancer - Summary - The Human Protein Atlas

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NOL12

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NOL12
Gene description	Nucleolar protein 12
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic and nucleolar expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA003547
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), cervical cancer (favourable), urothelial cancer (favourable) and lung cancer (favourable).
Renal cancer p<0.001 Cervical cancer p<0.001 Urothelial cancer p<0.001 Lung cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA003547

GENE INFORMATION
Gene name	NOL12 (HGNC Symbol)
Synonyms	MGC3731, Nop25, RRP17
Description	Nucleolar protein 12 (HGNC Symbol)
Entrez gene summary
Chromosome	22
Cytoband	q13.1
Chromosome location (bp)	37681673 - 37693478
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000273899 (version 83.38)
Entrez gene	79159
UniProt	Q9UGY1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UGY1
Antibodypedia	NOL12 antibodies

PROTEIN BROWSER

NOL12-001	NOL12-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NOL12-001 ENSP00000352021 ENST00000359114	Q9UGY1 [Direct mapping] Nucleolar protein 12 A0A024R1M6 [Target identity:100%; Query identity:100%] Uncharacterized protein Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005730 [nucleolus] GO:0019843 [rRNA binding] GO:0044822 [poly(A) RNA binding] Show all	213 aa 24.7 kDa	No	0
NOL12-201 ENSP00000482349 ENST00000611699	Q9UGY1 [Direct mapping] Nucleolar protein 12 A0A024R1M6 [Target identity:100%; Query identity:100%] Uncharacterized protein Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005730 [nucleolus] GO:0019843 [rRNA binding] GO:0044822 [poly(A) RNA binding] Show all	213 aa 24.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.