Cell atlas - TPTE - The Human Protein Atlas

GENERAL INFORMATION
Gene name	TPTE
Gene description	Transmembrane phosphatase with tensin homology
Protein class	Enzymes Plasma proteins Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol. In addition localized to the endoplasmic reticulum. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Cell line enhanced (K-562, BEWO, RPMI-8226, U-266/70, Karpas-707)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)
Additional location	In addition localized to the Endoplasmic reticulum (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA068342
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (K-562, BEWO, RPMI-8226, U-266/70, Karpas-707) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol. In addition localized to the endoplasmic reticulum. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Cytosol (approved)

Additional location

Endoplasmic reticulum (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA068342	MCF7	No staining
HPA068342	PC-3	Cytosol
HPA068342	U-2 OS	Endoplasmic reticulum
HPA068342	U-2 OS	Cytosol

GENE INFORMATION
Gene name	TPTE (HGNC Symbol)
Synonyms	CT44, PTEN2
Description	Transmembrane phosphatase with tensin homology (HGNC Symbol)
Entrez gene summary	This gene encodes a PTEN-related tyrosine phosphatase which may play a role in the signal transduction pathways of the endocrine or spermatogenic function of the testis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Chromosome	21
Cytoband	p11.2
Chromosome location (bp)	10521553 - 10606140
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000274391 (version 83.38)
Entrez gene	7179
UniProt	P56180 (UniProt - Evidence at transcript level)
neXtProt	NX_P56180
Antibodypedia	TPTE antibodies

PROTEIN BROWSER

TPTE-001	TPTE-002	TPTE-003	TPTE-004	TPTE-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TPTE-001 ENSP00000482040 ENST00000622113	P56180 [Direct mapping] Putative tyrosine-protein phosphatase TPTE Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005216 [ion channel activity] GO:0005515 [protein binding] GO:0006470 [protein dephosphorylation] GO:0006811 [ion transport] GO:0007165 [signal transduction] GO:0008138 [protein tyrosine/serine/threonine phosphatase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0055085 [transmembrane transport] Show all	533 aa 62.4 kDa	No	4
TPTE-002 ENSP00000484403 ENST00000618007	P56180 [Direct mapping] Putative tyrosine-protein phosphatase TPTE Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005216 [ion channel activity] GO:0005515 [protein binding] GO:0006470 [protein dephosphorylation] GO:0006811 [ion transport] GO:0007165 [signal transduction] GO:0008138 [protein tyrosine/serine/threonine phosphatase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0055085 [transmembrane transport] Show all	551 aa 64.3 kDa	No	4
TPTE-003 ENSP00000482488 ENST00000427445	P56180 [Direct mapping] Putative tyrosine-protein phosphatase TPTE Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005216 [ion channel activity] GO:0005515 [protein binding] GO:0006470 [protein dephosphorylation] GO:0006811 [ion transport] GO:0007165 [signal transduction] GO:0008138 [protein tyrosine/serine/threonine phosphatase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0055085 [transmembrane transport] Show all	513 aa 60.2 kDa	No	4
TPTE-004 ENSP00000483087 ENST00000612746	P56180 [Direct mapping] Putative tyrosine-protein phosphatase TPTE Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005216 [ion channel activity] GO:0005515 [protein binding] GO:0006470 [protein dephosphorylation] GO:0006811 [ion transport] GO:0007165 [signal transduction] GO:0008138 [protein tyrosine/serine/threonine phosphatase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0055085 [transmembrane transport] Show all	413 aa 49.3 kDa	No	2
TPTE-005 ENSP00000484064 ENST00000612957	A0A087X1C4 [Direct mapping] Putative tyrosine-protein phosphatase TPTE Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	140 aa 15.7 kDa	No	2