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DGKK

GENERAL INFORMATION

Gene name

 DGKK

Gene description

 Diacylglycerol kinase, kappa

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Not detected
HPA (cell line):Cell line enriched (Hep G2)
HPA (normal tissue):Tissue enriched (adrenal gland)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 DGKK

Synonyms

Description

 Diacylglycerol kinase, kappa (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is an enzyme that phosphorylates diacylglycerol, converting it to phosphatidic acid. The encoded protein is a membrane protein and is inhibited by hydrogen peroxide. Variations in this gene have been associated with hypospadias. [provided by RefSeq, Mar 2011]

Chromosome

 X

Cytoband

 p11.22

Chromosome location (bp)

 50365409 - 50470738

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000274588 (version 83.38)

Entrez gene

 139189

UniProt

 Q5KSL6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q5KSL6

Antibodypedia

 DGKK antibodies

PROTEIN BROWSER
DGKK-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DGKK-001
ENSP00000477515
ENST00000611977
Q5KSL6 [Direct mapping]
Diacylglycerol kinase kappa
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
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GO:0004143 [diacylglycerol kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006979 [response to oxidative stress]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0030168 [platelet activation]
GO:0035556 [intracellular signal transduction]
GO:0046339 [diacylglycerol metabolic process]
GO:0046872 [metal ion binding]
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 1271 aa
141.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.