Expression of SGK223 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

SGK223

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SGK223
Gene description	Tyrosine-protein kinase SgK223
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (A549)
HPA (normal tissue):	Tissue enhanced (thyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several different tissue types.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA012066
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA012066

GENE INFORMATION
Gene name	SGK223
Synonyms
Description	Tyrosine-protein kinase SgK223 (UniProtKB/Swiss-Prot)
Entrez gene summary	This gene encodes an enzyme that belongs to the tyrosine protein kinase family. A similar protein in rat binds to Rho family GTPase 2 (Rnd2) and regulates neurite outgrowth via activation of Ras homolog gene family, member A (RhoA). [provided by RefSeq, Mar 2014]
Chromosome	8
Cytoband	p23.1
Chromosome location (bp)	8317736 - 8386498
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000275342 (version 83.38)
Entrez gene	157285
UniProt	Q86YV5 (UniProt - Evidence at protein level)
neXtProt	NX_Q86YV5
Antibodypedia	SGK223 antibodies

PROTEIN BROWSER

SGK223-001	SGK223-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SGK223-001 ENSP00000481109 ENST00000615670	Q86YV5 [Target identity:100%; Query identity:100%] Tyrosine-protein kinase SgK223 Show all	Enzymes ENZYME proteins Transferases Kinases Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0018108 [peptidyl-tyrosine phosphorylation] Show all	1406 aa 149.6 kDa	No	0
SGK223-201 ENSP00000479068 ENST00000622241	Q86YV5 [Target identity:100%; Query identity:100%] Tyrosine-protein kinase SgK223 Show all	Enzymes ENZYME proteins Transferases Kinases Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0018108 [peptidyl-tyrosine phosphorylation] Show all	1406 aa 149.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.