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CCL15

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GENERAL INFORMATION

Gene name

 CCL15

Gene description

 Chemokine (C-C motif) ligand 15

Protein class

 Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the Golgi apparatus & vesicles.

RNA cell category

 Cell line enriched (Hep G2)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Golgi apparatus (approved), Vesicles (approved)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA058608
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (Hep G2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the Golgi apparatus & vesicles.

Main location

 Golgi apparatus (approved), Vesicles (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA058608 CACO-2 Golgi apparatus Intensity
Vesicles
HPA058608 Hep G2 Golgi apparatus

GENE INFORMATION

Gene name

 CCL15 (HGNC Symbol)

Synonyms

 HCC-2, HMRP-2B, Lkn-1, MIP-1d, MIP-5, NCC-3, SCYA15, SCYL3

Description

 Chemokine (C-C motif) ligand 15 (HGNC Symbol)

Entrez gene summary

 This gene is located in a cluster of similar genes in the same region of chromosome 17. These genes encode CC cytokines, which are secreted proteins characterized by two adjacent cysteines. The product of this gene is chemotactic for T cells and monocytes, and acts through C-C chemokine receptor type 1 (CCR1). The proprotein is further processed into numerous smaller functional peptides. Naturally-occurring readthrough transcripts occur from this gene into the downstream gene, CCL14 (chemokine (C-C motif) ligand 14). [provided by RefSeq, Jan 2013]

Chromosome

 17

Cytoband

 q12

Chromosome location (bp)

 35996440 - 36002038

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000275718 (version 83.38)

Entrez gene

 6359

UniProt

 Q16663 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16663

Antibodypedia

 CCL15 antibodies

PROTEIN BROWSER
CCL15-001
CCL15-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CCL15-001
ENSP00000484078
ENST00000617897
Q16663 [Direct mapping]
C-C motif chemokine 15 CCL15(22-92) CCL15(25-92) CCL15(29-92)
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
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GO:0002548 [monocyte chemotaxis]
GO:0005102 [receptor binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005623 [cell]
GO:0006874 [cellular calcium ion homeostasis]
GO:0006935 [chemotaxis]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0008009 [chemokine activity]
GO:0008201 [heparin binding]
GO:0030593 [neutrophil chemotaxis]
GO:0042056 [chemoattractant activity]
GO:0043547 [positive regulation of GTPase activity]
GO:0048020 [CCR chemokine receptor binding]
GO:0048245 [eosinophil chemotaxis]
GO:0048247 [lymphocyte chemotaxis]
GO:0050729 [positive regulation of inflammatory response]
GO:0050918 [positive chemotaxis]
GO:0070098 [chemokine-mediated signaling pathway]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071346 [cellular response to interferon-gamma]
GO:0071347 [cellular response to interleukin-1]
GO:0071356 [cellular response to tumor necrosis factor]
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 113 aa
12.2 kDa 		Yes 0
CCL15-002
ENSP00000484262
ENST00000614368
A0A087X1J9 [Direct mapping]
C-C motif chemokine 15
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Predicted intracellular proteins
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GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006955 [immune response]
GO:0008009 [chemokine activity]
GO:0060326 [cell chemotaxis]
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 61 aa
6.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.