Expression of PRSS2 in cancer - Summary - The Human Protein Atlas

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PRSS2

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PRSS2
Gene description	Protease, serine, 2 (trypsin 2)
Protein class	Enzymes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (pancreatic cancer)
HPA (cell line):	Group enriched (RPMI-8226, U-2 OS)
HPA (normal tissue):	Tissue enriched (pancreas)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in pancreas

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Supported based on 2 antibodies. HPA062452 , HPA063471
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PROGNOSTIC SUMMARY
Prognostic marker in breast cancer (favourable).
Breast cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (pancreatic cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA062452	HPA063471

GENE INFORMATION
Gene name	PRSS2 (HGNC Symbol)
Synonyms	TRY2
Description	Protease, serine, 2 (trypsin 2) (HGNC Symbol)
Entrez gene summary	This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2015]
Chromosome	7
Cytoband	q34
Chromosome location (bp)	142748662 - 142774564
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000275896 (version 83.38)
Entrez gene	5645
UniProt	P07478 (UniProt - Evidence at protein level)
neXtProt	NX_P07478
Antibodypedia	PRSS2 antibodies

PROTEIN BROWSER

PRSS2-001	PRSS2-201	PRSS2-202	PRSS2-203	PRSS2-204	PRSS2-205

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PRSS2-001 ENSP00000488338 ENST00000539842	P07478 [Target identity:100%; Query identity:100%] Trypsin-2 Q5NV56 [Target identity:100%; Query identity:100%] Anionic trypsinogen; Protease, serine, 2 (Trypsin 2); Protease, serine, 2 (Trypsin 2), isoform CRA_a; Trypsinogen E Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0007586 [digestion] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0030307 [positive regulation of cell growth] GO:0030574 [collagen catabolic process] GO:0031012 [extracellular matrix] GO:0045087 [innate immune response] GO:0045785 [positive regulation of cell adhesion] Show all	247 aa 26.5 kDa	Yes	0
PRSS2-201 ENSP00000488077 ENST00000632805	A6XMV8 [Target identity:100%; Query identity:100%] Protease serine 2 preproprotein Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	246 aa 26.7 kDa	Yes	0
PRSS2-202 ENSP00000488789 ENST00000632998		SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	247 aa 26.4 kDa	Yes	0
PRSS2-203 ENSP00000487822 ENST00000633114		SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	249 aa 26.8 kDa	Yes	0
PRSS2-204 ENSP00000488437 ENST00000633969	A6XMV9 [Target identity:100%; Query identity:100%] Protease serine 2 preproprotein Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	261 aa 28 kDa	Yes	0
PRSS2-205 ENSP00000488594 ENST00000634019		SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	261 aa 28.2 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.