Expression of DUSP14 in cancer - Summary - The Human Protein Atlas

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DUSP14

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DUSP14
Gene description	Dual specificity phosphatase 14
Protein class	Cancer-related genes Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (BJ hTERT+ SV40 Large T+, BJ hTERT+ SV40 Large T+ RasG12V, HBF TERT88, WM-115)
HPA (normal tissue):	Tissue enhanced (fallopian tube)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA019911
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA019911

GENE INFORMATION
Gene name	DUSP14 (HGNC Symbol)
Synonyms	MKP-L, MKP6
Description	Dual specificity phosphatase 14 (HGNC Symbol)
Entrez gene summary	Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP14 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]
Chromosome	17
Cytoband	q12
Chromosome location (bp)	37489831 - 37513501
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000276023 (version 83.38)
Entrez gene	11072
UniProt	O95147 (UniProt - Evidence at protein level)
neXtProt	NX_O95147
Antibodypedia	DUSP14 antibodies

PROTEIN BROWSER

DUSP14-001	DUSP14-002	DUSP14-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DUSP14-001 ENSP00000478595 ENST00000617516	O95147 [Direct mapping] Dual specificity protein phosphatase 14 Q6FI36 [Target identity:100%; Query identity:100%] DUSP14 protein; Dual specificity phosphatase 14, isoform CRA_a; cDNA, FLJ95796, Homo sapiens dual specificity phosphatase 14 (DUSP14), mRNA Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Show all	GO:0000188 [inactivation of MAPK activity] GO:0004725 [protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0006470 [protein dephosphorylation] GO:0008138 [protein tyrosine/serine/threonine phosphatase activity] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0017017 [MAP kinase tyrosine/serine/threonine phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0044822 [poly(A) RNA binding] Show all	198 aa 22.3 kDa	No	0
DUSP14-002 ENSP00000484091 ENST00000613659	O95147 [Direct mapping] Dual specificity protein phosphatase 14 Q6FI36 [Target identity:100%; Query identity:100%] DUSP14 protein; Dual specificity phosphatase 14, isoform CRA_a; cDNA, FLJ95796, Homo sapiens dual specificity phosphatase 14 (DUSP14), mRNA Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Show all	GO:0000188 [inactivation of MAPK activity] GO:0004725 [protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0006470 [protein dephosphorylation] GO:0008138 [protein tyrosine/serine/threonine phosphatase activity] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0017017 [MAP kinase tyrosine/serine/threonine phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0044822 [poly(A) RNA binding] Show all	198 aa 22.3 kDa	No	0
DUSP14-003 ENSP00000477653 ENST00000614411	O95147 [Direct mapping] Dual specificity protein phosphatase 14 Q6FI36 [Target identity:100%; Query identity:100%] DUSP14 protein; Dual specificity phosphatase 14, isoform CRA_a; cDNA, FLJ95796, Homo sapiens dual specificity phosphatase 14 (DUSP14), mRNA Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Show all	GO:0000188 [inactivation of MAPK activity] GO:0004725 [protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0006470 [protein dephosphorylation] GO:0008138 [protein tyrosine/serine/threonine phosphatase activity] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0017017 [MAP kinase tyrosine/serine/threonine phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0044822 [poly(A) RNA binding] Show all	198 aa 22.3 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.