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CCL3L3

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GENERAL INFORMATION

Gene name

 CCL3L3

Gene description

 Chemokine (C-C motif) ligand 3-like 3

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Group enriched (U-266/84, U-266/70)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (U-266/84, U-266/70)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 CCL3L3 (HGNC Symbol)

Synonyms

 MGC12815

Description

 Chemokine (C-C motif) ligand 3-like 3 (HGNC Symbol)

Entrez gene summary

 This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this gene binds to several chemokine receptors, including chemokine binding protein 2 and chemokine (C-C motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The copy number of this gene varies among individuals, where most individuals have one to six copies, and a minority of individuals have zero or more than six copies. There are conflicting reports about copy number variation of this gene and its correlation to disease susceptibility.[provided by RefSeq, Apr 2014]

Chromosome

 17

Cytoband

 q12

Chromosome location (bp)

 36194869 - 36196758

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000276085 (version 83.38)

Entrez gene

 414062

UniProt

 P16619 (UniProt - Evidence at protein level)

neXtProt

 NX_P16619

Antibodypedia

 CCL3L3 antibodies

PROTEIN BROWSER
CCL3L3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CCL3L3-001
ENSP00000480558
ENST00000619989
P16619 [Direct mapping]
C-C motif chemokine 3-like 1 LD78-beta(3-70) LD78-beta(5-70)
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0002548 [monocyte chemotaxis]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0008009 [chemokine activity]
GO:0008285 [negative regulation of cell proliferation]
GO:0030593 [neutrophil chemotaxis]
GO:0043547 [positive regulation of GTPase activity]
GO:0048020 [CCR chemokine receptor binding]
GO:0048245 [eosinophil chemotaxis]
GO:0048247 [lymphocyte chemotaxis]
GO:0050729 [positive regulation of inflammatory response]
GO:0070098 [chemokine-mediated signaling pathway]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071346 [cellular response to interferon-gamma]
GO:0071347 [cellular response to interleukin-1]
GO:0071356 [cellular response to tumor necrosis factor]
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 93 aa
10.2 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.