Fields »
ABOUT
HELP
BLOG
PIK3R6

GENERAL INFORMATION

Gene name

 PIK3R6

Gene description

 Phosphoinositide-3-kinase, regulatory subunit 6

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enriched (HMC-1)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissue types.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA023077
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA023077

GENE INFORMATION

Gene name

 PIK3R6 (HGNC Symbol)

Synonyms

 C17orf38, FLJ34500, HsT41028, p87PIKAP

Description

 Phosphoinositide-3-kinase, regulatory subunit 6 (HGNC Symbol)

Entrez gene summary

 Phosphoinositide 3-kinase gamma is a lipid kinase that produces the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate. The kinase is composed of a catalytic subunit and one of several regulatory subunits, and is chiefly activated by G protein-coupled receptors. This gene encodes a regulatory subunit, and is distantly related to the phosphoinositide-3-kinase, regulatory subunit 5 gene which is located adjacent to this gene on chromosome 7. The orthologous protein in the mouse binds to both the catalytic subunit and to G(beta/gamma), and mediates activation of the kinase subunit downstream of G protein-coupled receptors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Chromosome

 17

Cytoband

 p13.1

Chromosome location (bp)

 8802723 - 8867677

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000276231 (version 83.38)

Entrez gene

 146850

UniProt

 Q5UE93 (UniProt - Evidence at protein level)

neXtProt

 NX_Q5UE93

Antibodypedia

 PIK3R6 antibodies

PROTEIN BROWSER
PIK3R6-002
PIK3R6-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PIK3R6-002
ENSP00000482341
ENST00000614407
Q5UE93 [Direct mapping]
Phosphoinositide 3-kinase regulatory subunit 6
Show all
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0001525 [angiogenesis]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005944 [phosphatidylinositol 3-kinase complex, class IB]
GO:0006644 [phospholipid metabolic process]
GO:0006661 [phosphatidylinositol biosynthetic process]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0016020 [membrane]
GO:0030168 [platelet activation]
GO:0042269 [regulation of natural killer cell mediated cytotoxicity]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043551 [regulation of phosphatidylinositol 3-kinase activity]
GO:0044281 [small molecule metabolic process]
GO:0045766 [positive regulation of angiogenesis]
GO:0046934 [phosphatidylinositol-4,5-bisphosphate 3-kinase activity]
GO:0046935 [1-phosphatidylinositol-3-kinase regulator activity]
Show all
 754 aa
84.3 kDa 		No 0
PIK3R6-201
ENSP00000480157
ENST00000619866
Q5UE93 [Direct mapping]
Phosphoinositide 3-kinase regulatory subunit 6
Show all
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005944 [phosphatidylinositol 3-kinase complex, class IB]
GO:0006644 [phospholipid metabolic process]
GO:0006661 [phosphatidylinositol biosynthetic process]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0016020 [membrane]
GO:0030168 [platelet activation]
GO:0042269 [regulation of natural killer cell mediated cytotoxicity]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043551 [regulation of phosphatidylinositol 3-kinase activity]
GO:0044281 [small molecule metabolic process]
GO:0045582 [positive regulation of T cell differentiation]
GO:0045766 [positive regulation of angiogenesis]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0046934 [phosphatidylinositol-4,5-bisphosphate 3-kinase activity]
GO:0046935 [1-phosphatidylinositol-3-kinase regulator activity]
Show all
 754 aa
84.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.