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CCL14

GENERAL INFORMATION

Gene name

 CCL14

Gene description

 Chemokine (C-C motif) ligand 14

Protein class

 Cancer-related genes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enriched (HUVEC TERT2)
HPA (normal tissue):Tissue enhanced (spleen)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most cell types.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Uncertain based on 2 antibodies.
HPA030268 , CAB004423
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA030268
CAB004423

GENE INFORMATION

Gene name

 CCL14 (HGNC Symbol)

Synonyms

 CKb1, HCC-1, HCC-3, MCIF, NCC-2, SCYA14, SCYL2

Description

 Chemokine (C-C motif) ligand 14 (HGNC Symbol)

Entrez gene summary

 This gene, chemokine (C-C motif) ligand 14, is one of several CC cytokine genes clustered on 17q11.2. The CC cytokines are secreted proteins characterized by two adjacent cysteines. The cytokine encoded by this gene induces changes in intracellular calcium concentration and enzyme release in monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Read-through transcripts are also expressed that include exons from the upstream cytokine gene, chemokine (C-C motif) ligand 15, and are represented as GeneID: 348249. [provided by RefSeq, Dec 2009]

Chromosome

 17

Cytoband

 q12

Chromosome location (bp)

 35983291 - 35987004

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000276409 (version 83.38)

Entrez gene

 6358

UniProt

 Q16627 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16627

Antibodypedia

 CCL14 antibodies

PROTEIN BROWSER
CCL14-001
CCL14-002
CCL14-003
CCL14-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CCL14-001
ENSP00000481023
ENST00000618404
Q16627 [Direct mapping]
C-C motif chemokine 14 HCC-1(3-74) HCC-1(4-74) HCC-1(9-74)
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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
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GO:0002548 [monocyte chemotaxis]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005623 [cell]
GO:0006874 [cellular calcium ion homeostasis]
GO:0006955 [immune response]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0008009 [chemokine activity]
GO:0008284 [positive regulation of cell proliferation]
GO:0030593 [neutrophil chemotaxis]
GO:0043547 [positive regulation of GTPase activity]
GO:0048020 [CCR chemokine receptor binding]
GO:0048245 [eosinophil chemotaxis]
GO:0048247 [lymphocyte chemotaxis]
GO:0050729 [positive regulation of inflammatory response]
GO:0070098 [chemokine-mediated signaling pathway]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071346 [cellular response to interferon-gamma]
GO:0071347 [cellular response to interleukin-1]
GO:0071356 [cellular response to tumor necrosis factor]
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 93 aa
10.7 kDa 		Yes 0
CCL14-002
ENSP00000479097
ENST00000622526
Q16627 [Direct mapping]
C-C motif chemokine 14 HCC-1(3-74) HCC-1(4-74) HCC-1(9-74)
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Show all
GO:0002548 [monocyte chemotaxis]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005623 [cell]
GO:0006874 [cellular calcium ion homeostasis]
GO:0006955 [immune response]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0008009 [chemokine activity]
GO:0008284 [positive regulation of cell proliferation]
GO:0030593 [neutrophil chemotaxis]
GO:0043547 [positive regulation of GTPase activity]
GO:0048020 [CCR chemokine receptor binding]
GO:0048245 [eosinophil chemotaxis]
GO:0048247 [lymphocyte chemotaxis]
GO:0050729 [positive regulation of inflammatory response]
GO:0070098 [chemokine-mediated signaling pathway]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071346 [cellular response to interferon-gamma]
GO:0071347 [cellular response to interleukin-1]
GO:0071356 [cellular response to tumor necrosis factor]
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 109 aa
12.3 kDa 		Yes 0
CCL14-003
ENSP00000483186
ENST00000614009
A0A087X089 [Direct mapping]
C-C motif chemokine
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006955 [immune response]
GO:0008009 [chemokine activity]
GO:0060326 [cell chemotaxis]
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 115 aa
13.1 kDa 		Yes 0
CCL14-004
ENSP00000484818
ENST00000620991
A0A0B4J2G5 [Direct mapping]
C-C motif chemokine 14
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0005576 [extracellular region]
GO:0006955 [immune response]
GO:0008009 [chemokine activity]
GO:0060326 [cell chemotaxis]
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 65 aa
7.4 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.