Expression of F8A1 in cancer - Summary - The Human Protein Atlas

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F8A1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	F8A1
Gene description	Coagulation factor VIII-associated 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several different tissue types.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification. Caution, targets protein from more than one gene.
Reliability score	Uncertain based on 1 antibody. HPA046960
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (favourable).
Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA046960

GENE INFORMATION
Gene name	F8A1 (HGNC Symbol)
Synonyms	DXS522E, F8A
Description	Coagulation factor VIII-associated 1 (HGNC Symbol)
Entrez gene summary	This gene is contained entirely within intron 22 of the factor VIII gene; spans less than 2 kb, and is transcribed in the direction opposite of factor VIII. A portion of intron 22 (int22h), containing F8A, is repeated twice extragenically closer to the Xq telomere. Although its function is unknown, the observation that this gene is conserved in the mouse implies it has some function. Unlike factor VIII, this gene is transcribed abundantly in a wide variety of cell types. [provided by RefSeq, Jul 2008]
Chromosome	X
Cytoband	q28
Chromosome location (bp)	154886349 - 154888061
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000277203 (version 83.38)
Entrez gene	8263
UniProt	P23610 (UniProt - Evidence at protein level)
neXtProt	NX_P23610
Antibodypedia	F8A1 antibodies

PROTEIN BROWSER

F8A1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
F8A1-001 ENSP00000479624 ENST00000610495	P23610 [Direct mapping] Factor VIII intron 22 protein Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all	GO:0003674 [molecular_function] GO:0005634 [nucleus] GO:0008150 [biological_process] Show all	371 aa 39.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.