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GPIHBP1

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GENERAL INFORMATION

Gene name

 GPIHBP1

Gene description

 Glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1

Protein class

 Disease related genes
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (Karpas-707)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (Karpas-707)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 GPIHBP1 (HGNC Symbol)

Synonyms

 GPI-HBP1, LOC338328

Description

 Glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a capillary endothelial cell protein that facilitates the lipolytic processing of triglyceride-rich lipoproteins. The encoded protein is a glycosylphosphatidylinositol-anchored protein that is a member of the lymphocyte antigen 6 (Ly6) family. This protein plays a major role in transporting lipoprotein lipase (LPL) from the subendothelial spaces to the capillary lumen. Mutations in this gene are the cause of hyperlipoproteinemia, type 1D. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

Chromosome

 8

Cytoband

 q24.3

Chromosome location (bp)

 143213193 - 143217170

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000277494 (version 83.38)

Entrez gene

 338328

UniProt

 Q8IV16 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8IV16

Antibodypedia

 GPIHBP1 antibodies

PROTEIN BROWSER
GPIHBP1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GPIHBP1-001
ENSP00000480053
ENST00000622500
Q8IV16 [Direct mapping]
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1
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   SCAMPI predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Show all
GO:0005622 [intracellular]
GO:0006869 [lipid transport]
GO:0006886 [intracellular protein transport]
GO:0008035 [high-density lipoprotein particle binding]
GO:0008289 [lipid binding]
GO:0008320 [protein transmembrane transporter activity]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0017038 [protein import]
GO:0031362 [anchored component of external side of plasma membrane]
GO:0034364 [high-density lipoprotein particle]
GO:0034394 [protein localization to cell surface]
GO:0035473 [lipase binding]
GO:0035478 [chylomicron binding]
GO:0042632 [cholesterol homeostasis]
GO:0045056 [transcytosis]
GO:0046658 [anchored component of plasma membrane]
GO:0050821 [protein stabilization]
GO:0051006 [positive regulation of lipoprotein lipase activity]
GO:0070328 [triglyceride homeostasis]
GO:0071503 [response to heparin]
GO:0071806 [protein transmembrane transport]
GO:0071813 [lipoprotein particle binding]
GO:0090321 [positive regulation of chylomicron remnant clearance]
Show all
 184 aa
19.8 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.