Expression of TBC1D3C in cancer - Summary - The Human Protein Atlas

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TBC1D3C

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TBC1D3C
Gene description	TBC1 domain family, member 3C
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Cell line enhanced (CAPAN-2, T-47d)
HPA (normal tissue):	Tissue enhanced (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, including testis.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification. Caution, targets protein from more than one gene.
Reliability score	Approved based on 3 antibodies. HPA046969 , HPA047745 , HPA052553
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA046969	HPA047745	HPA052553

GENE INFORMATION
Gene name	TBC1D3C (HGNC Symbol)
Synonyms	MGC44903
Description	TBC1 domain family, member 3C (HGNC Symbol)
Entrez gene summary	This gene represents one of a cluster of related genes found on chromosome 17. The proteins encoded by this gene family contain a TBC (Tre-2, Bub2p, and Cdc16p) domain and may be involved in GTPase signaling and vesicle trafficking. [provided by RefSeq, Apr 2014]
Chromosome	17
Cytoband	q12
Chromosome location (bp)	37978470 - 38068592
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000278299 (version 83.38)
Entrez gene	414060
UniProt	Q6IPX1 (UniProt - Evidence at transcript level)
neXtProt	NX_Q6IPX1
Antibodypedia	TBC1D3C antibodies

PROTEIN BROWSER

TBC1D3C-001	TBC1D3C-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TBC1D3C-001 ENSP00000482345 ENST00000622206	Q6IPX1 [Direct mapping] TBC1 domain family member 3C Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005096 [GTPase activator activity] GO:0005886 [plasma membrane] GO:0043547 [positive regulation of GTPase activity] Show all	549 aa 62.2 kDa	No	1
TBC1D3C-201 ENSP00000480107 ENST00000617125		Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all		549 aa 62.2 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.