Expression of DHRS11 in cancer - Summary - The Human Protein Atlas

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DHRS11

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DHRS11
Gene description	Dehydrogenase/reductase (SDR family) member 11
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Group enriched (colon, duodenum, rectum, small intestine)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Secreted positivity in gastrointestinal tract.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Supported based on 3 antibodies. HPA041226 , HPA048236 , HPA053623
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA041226	HPA048236	HPA053623

GENE INFORMATION
Gene name	DHRS11 (HGNC Symbol)
Synonyms	MGC4172, SDR24C1
Description	Dehydrogenase/reductase (SDR family) member 11 (HGNC Symbol)
Entrez gene summary
Chromosome	17
Cytoband	q12
Chromosome location (bp)	36591798 - 36600806
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000278535 (version 83.38)
Entrez gene	79154
UniProt	Q6UWP2 (UniProt - Evidence at protein level)
neXtProt	NX_Q6UWP2
Antibodypedia	DHRS11 antibodies

PROTEIN BROWSER

DHRS11-001	DHRS11-002	DHRS11-004	DHRS11-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DHRS11-001 ENSP00000482704 ENST00000618403	Q6UWP2 [Direct mapping] Dehydrogenase/reductase SDR family member 11 A0A024R0T1 [Target identity:100%; Query identity:100%] Short-chain dehydrogenase/reductase, isoform CRA_b Show all	TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005576 [extracellular region] GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	260 aa 28.3 kDa	No	0
DHRS11-002 ENSP00000482777 ENST00000615432	A0A087WZN3 [Direct mapping] Dehydrogenase/reductase SDR family member 11 Show all	Predicted intracellular proteins Show all	GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	150 aa 16.6 kDa	No	0
DHRS11-004 ENSP00000477603 ENST00000611337	Q6UWP2 [Direct mapping] Dehydrogenase/reductase SDR family member 11 Show all	Predicted intracellular proteins Show all	GO:0005576 [extracellular region] GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	181 aa 20 kDa	No	0
DHRS11-007 ENSP00000483596 ENST00000621871	A0A087X0R1 [Direct mapping] Dehydrogenase/reductase SDR family member 11 Show all	Predicted intracellular proteins Show all	GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	109 aa 12.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.