Tissue expression of NR2E3 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	NR2E3
Gene description	Nuclear receptor subfamily 2, group E, member 3
Protein class	Disease related genes Nuclear receptors Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Not detected
FANTOM5:	Tissue enriched (retina)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Not detected
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (retina)

GENE INFORMATION
Gene name	NR2E3 (HGNC Symbol)
Synonyms	PNR, rd7, RP37
Description	Nuclear receptor subfamily 2, group E, member 3 (HGNC Symbol)
Entrez gene summary	This protein is part of a large family of nuclear receptor transcription factors involved in signaling pathways. Nuclear receptors have been shown to regulate pathways involved in embryonic development, as well as in maintenance of proper cell function in adults. Members of this family are characterized by discrete domains that function in DNA and ligand binding. This gene encodes a retinal nuclear receptor that is a ligand-dependent transcription factor. Defects in this gene are a cause of enhanced S cone syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Chromosome	15
Cytoband	q23
Chromosome location (bp)	71792638 - 71818259
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000278570 (version 83.38)
Entrez gene	10002
UniProt	Q9Y5X4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y5X4
Antibodypedia	NR2E3 antibodies

PROTEIN BROWSER

NR2E3-001	NR2E3-002	NR2E3-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NR2E3-001 ENSP00000482504 ENST00000617575	Q9Y5X4 [Direct mapping] Photoreceptor-specific nuclear receptor Show all	Nuclear receptors Phobius predicted secreted proteins Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003707 [steroid hormone receptor activity] GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0007601 [visual perception] GO:0007602 [phototransduction] GO:0008270 [zinc ion binding] GO:0008285 [negative regulation of cell proliferation] GO:0010467 [gene expression] GO:0030522 [intracellular receptor signaling pathway] GO:0042462 [eye photoreceptor cell development] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0045872 [positive regulation of rhodopsin gene expression] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0060041 [retina development in camera-type eye] Show all	410 aa 44.7 kDa	No	0
NR2E3-002 ENSP00000479962 ENST00000621098	Q9Y5X4 [Direct mapping] Photoreceptor-specific nuclear receptor F1D8Q9 [Target identity:100%; Query identity:100%] Nuclear receptor subfamily 2, group E, member 3, isoform CRA_b; Photoreceptor cell-specific nuclear receptor variant 1 Show all	Nuclear receptors Phobius predicted secreted proteins Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003707 [steroid hormone receptor activity] GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0007601 [visual perception] GO:0007602 [phototransduction] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0030522 [intracellular receptor signaling pathway] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] Show all	367 aa 39.6 kDa	No	0
NR2E3-004 ENSP00000479254 ENST00000621736	Q8IVZ9 [Direct mapping] NR2E3 protein; Photoreceptor-specific nuclear receptor Show all	Nuclear receptors Predicted intracellular proteins Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003707 [steroid hormone receptor activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] Show all	322 aa 35.5 kDa	No	0