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General nuclear expression. Additional cytoplasmic expression in a few tissues.
ANTIBODY IHC RELIABILITY
Data reliability description
Caution, targets protein from more than one gene. External characterization data supports antibody staining. Caution, Splice and/or transcript discrepancy exists.
Most cancer tissues showed weak to moderate nuclear staining. Most renal and liver cancers were negative.
GENE INFORMATION
Gene name
ATRIP
Synonyms
Description
ATR interacting protein (EntrezGene)
Entrez gene summary
This gene encodes an essential component of the DNA damage checkpoint. The encoded protein binds to single-stranded DNA coated with replication protein A. The protein also interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2012]