Cell atlas - AKR1C3 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	AKR1C3
Gene description	Aldo-keto reductase family 1, member C3
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus & cytosol. In addition localized to the endoplasmic reticulum & nucleoli (fibrillar center). Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Cell line enhanced (A549, AN3-CA, RT4)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (approved), Cytosol (approved)
Additional location	In addition localized to the Nucleoli fibrillar center (approved), Endoplasmic reticulum (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA068265
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (A549, AN3-CA, RT4) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus & cytosol. In addition localized to the endoplasmic reticulum & nucleoli (fibrillar center). Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Nucleus (approved), Cytosol (approved)

Additional location

Nucleoli fibrillar center (approved), Endoplasmic reticulum (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation
HPA068265	A549	Nucleus	Spatial
		Nucleoli fibrillar center	Spatial
		Endoplasmic reticulum
		Cytosol	Spatial
HPA068265	Hep G2	Nucleus	Spatial
		Nucleoli fibrillar center
		Endoplasmic reticulum
		Cytosol	Spatial
HPA068265	U-2 OS	Nucleoli fibrillar center

GENE INFORMATION
Gene name	AKR1C3
Synonyms
Description	Aldo-keto reductase family 1, member C3 (EntrezGene)
Entrez gene summary	This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Chromosome	10
Cytoband	p15.1
Chromosome location (bp)	5048812 - 5107503
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000282883 (version 83.38)
Entrez gene	8644
UniProt
neXtProt
Antibodypedia	AKR1C3 antibodies

PROTEIN BROWSER

AKR1C3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AKR1C3-201 ENSP00000401327 ENST00000439082	A0A0A0MSS8 [Direct mapping] Aldo-keto reductase family 1 member C3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	323 aa 36.9 kDa	No	0