The human protein atlas blog


Prognostic genes in pancreatic cancer

2017-11-17
Cancer Immunohistochemistry Pancreatic cancer Pathology Atlas TCGA tissue

Figure 1. Immunohistochemical staining of MUC1 shows differential expression pattern, high (left panel) and low (right panel) in

Next in our series of articles on cancer is Pancreatic cancer, a relatively rare cancer associated with very poor prognosis. The vast majority of tumors originate from ductal cells and a small fraction are endocrine tumors. Over 80% of pancreatic cancers develop at ages above 60 years and most tumors are detected at late stages of the disease when the cancer has spread beyond the pancreas.

There is a great need for biomarkers to facilitate early detection and help establishment of diagnosis. Smoking, obesity, physical inactivity and long-lasting inflammation in the pancreas are some of the factors that lead to an increased risk of pancreatic cancer...Read more


650 genes associated with prognosis in Lung Cancer

2017-10-13
Cancer CancerProteomics Immunohistochemistry Lung cancer Pathology Atlas Proteomics TCGA

Figure 1. Immunohistochemical staining of MPC1 using antibody HPA045119 shows differential expression pattern, both high (left panel) and low (right panel), in samples from lung cancer patients.

As part of the release Pathology Atlas release, the Human Protein Atlas will each week present a brief and informative summary highlighting genes with prognostic association in different cancer forms. This week, we will focus on Lung cancer one of the deadliest cancers in the world today.

Lung cancer patients have a poor outcome with a 5-year survival rate of 13.6% in men and 19.4% in women. Late diagnosis and lack of effective treatments are considered to contribute to poor prognosis. Smoking is the leading risk factor and is responsible for 70-90% of the lung cancer cases. Lung cancer can be divided into small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC)...Read more


Ovarian Cancer Awareness Month

2017-09-29
Cancer Immunohistochemistry Life Science Ovarian cancer awareness Pathology Atlas Plasma Profilling TCGA tissue

Figure 1. Immunohistochemical staining of EPCAM using antibody CAB055098 shows differential expression, both high (left panel) and low (right panel) in samples from ovarian cancer patients.

In this week's Pathology Atlas blog post, we highlight genes with prognostic association to ovarian cancer , as September is National Ovarian Cancer Awareness Month in the US. Ovarian cancer is the fifth most frequent cause of cancer death in women, and 50% of all ovarian cancers are diagnosed in women older than 65 years of age.

Epithelial ovarian carcinoma is one of the most common gynecologic malignancy. There are five subtypes of epithelial ovarian carcinoma, of which high-grade serous carcinoma is the most common...Read more


Awareness for prostate cancer

2017-09-27
European Prostate Cancer Awareness Day Immunohistochemistry Life Science Pathology Atlas Prostate cancer Prostate Cancer Awareness Month TCGA tissue

Figure 1. Immunohistochemical staining of ODF2 using antibody HPA001874 shows differential expression in samples from prostate cancer patients.

As part of the release of the Pathology Atlas, the Human Protein Atlas Blog presents brief and informative summaries of most cancers, and highlight genes with prognostic association in the different cancer forms. The Pathology Atlas is an open access database which includes quantitative transcriptomics data and spatial proteomics data of the major human cancer types that have been analyzed using a systems level approach.

We focus on prostate cancer in this week's blog post to highlight Prostate Cancer Awareness Month in North America and the European Prostate Cancer Awareness Day on the 27th of September...Read more


Human Protein Atlas presentations at the 16th HUPO World Congress

2017-09-14
Affinity proteomics Cell Atlas Conference Human Protein Atlas Immunofluorescence microscopy Immunohistochemistry Sub-cellular structures Tissue Atlas

Next week on the 17th to 21th of September, the human proteome organization (HUPO), is hosting the 16th HUPO World Congress in Dublin, Ireland. Several Human Protein Atlas-associated researchers will attend the meeting and represent the project in various sessions, including plenary and invited lectures, oral presentations and poster sessions.

HUPO is an international scientific organization representing and promoting proteomics through international cooperation and collaborations by fostering the development of new technologies, techniques and training...Read more


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