Cell atlas - SCYL3 - The Human Protein Atlas

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SCYL3

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Microtubules
	Nuclear bodies

Human cell
	Microtubules
	Nucleoplasm

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GENERAL INFORMATION
Gene name	SCYL3
Gene description	SCY1-like, kinase-like 3
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the microtubules. In addition localized to the nuclear bodies.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Microtubules (uncertain)
Additional location	In addition localized to the Nuclear bodies (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA005624
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the microtubules. In addition localized to the nuclear bodies.

Main location

Microtubules (uncertain)

Additional location

Nuclear bodies (uncertain)


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Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA005624	A-431	Nuclear bodies
	HPA005624	A-431	Microtubules
	HPA005624	U-2 OS	Microtubules
	HPA005624	U-251 MG	Nuclear bodies
	HPA005624	U-251 MG	Microtubules

GENE INFORMATION
Gene name	SCYL3 (HGNC Symbol)
Synonyms	PACE-1, PACE1
Description	SCY1-like, kinase-like 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein with a kinase domain and four HEAT repeats. The encoded protein interacts with the C-terminal domain of ezrin, an ERM protein, and may play a role in cell adhesion and migration. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Jun 2012]
Chromosome	1
Cytoband	q24.2
Chromosome location (bp)	169849631 - 169894267
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000000457 (version 83.38)
Entrez gene	57147
UniProt	Q8IZE3 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IZE3
Antibodypedia	SCYL3 antibodies

PROTEIN BROWSER

SCYL3-001	SCYL3-002	SCYL3-003	SCYL3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SCYL3-001 ENSP00000356745 ENST00000367771	Q8IZE3 [Direct mapping] Protein-associating with the carboxyl-terminal domain of ezrin Show all	Enzymes Kinases THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0006468 [protein phosphorylation] GO:0016477 [cell migration] GO:0030027 [lamellipodium] Show all	688 aa 76.7 kDa	No	0
SCYL3-002 ENSP00000407993 ENST00000423670	X6RHX1 [Direct mapping] Protein-associating with the carboxyl-terminal domain of ezrin Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005488 [binding] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	588 aa 65.3 kDa	No	0
SCYL3-003 ENSP00000356744 ENST00000367770	Q8IZE3 [Direct mapping] Protein-associating with the carboxyl-terminal domain of ezrin Show all	Enzymes Kinases THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0006468 [protein phosphorylation] GO:0016477 [cell migration] GO:0030027 [lamellipodium] Show all	742 aa 82.9 kDa	No	0
SCYL3-201 ENSP00000356746 ENST00000367772	Q8IZE3 [Direct mapping] Protein-associating with the carboxyl-terminal domain of ezrin Show all	Enzymes Kinases THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0006468 [protein phosphorylation] GO:0016477 [cell migration] GO:0030027 [lamellipodium] Show all	742 aa 82.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.