Expression of SCYL3 in cancer - Summary

GENERAL INFORMATION
Gene name	SCYL3
Gene description	SCY1-like, kinase-like 3
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression, most abundant in endothelial cells and placental trophoblasts.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA005624
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (favourable).
Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA005624

GENE INFORMATION
Gene name	SCYL3 (HGNC Symbol)
Synonyms	PACE-1, PACE1
Description	SCY1-like, kinase-like 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein with a kinase domain and four HEAT repeats. The encoded protein interacts with the C-terminal domain of ezrin, an ERM protein, and may play a role in cell adhesion and migration. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Jun 2012]
Chromosome	1
Cytoband	q24.2
Chromosome location (bp)	169849631 - 169894267
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000000457 (version 83.38)
Entrez gene	57147
UniProt	Q8IZE3 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IZE3
Antibodypedia	SCYL3 antibodies

PROTEIN BROWSER

SCYL3-001	SCYL3-002	SCYL3-003	SCYL3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SCYL3-001 ENSP00000356745 ENST00000367771	Q8IZE3 [Direct mapping] Protein-associating with the carboxyl-terminal domain of ezrin Show all	Enzymes Kinases THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0006468 [protein phosphorylation] GO:0016477 [cell migration] GO:0030027 [lamellipodium] Show all	688 aa 76.7 kDa	No	0
SCYL3-002 ENSP00000407993 ENST00000423670	X6RHX1 [Direct mapping] Protein-associating with the carboxyl-terminal domain of ezrin Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005488 [binding] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	588 aa 65.3 kDa	No	0
SCYL3-003 ENSP00000356744 ENST00000367770	Q8IZE3 [Direct mapping] Protein-associating with the carboxyl-terminal domain of ezrin Show all	Enzymes Kinases THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0006468 [protein phosphorylation] GO:0016477 [cell migration] GO:0030027 [lamellipodium] Show all	742 aa 82.9 kDa	No	0
SCYL3-201 ENSP00000356746 ENST00000367772	Q8IZE3 [Direct mapping] Protein-associating with the carboxyl-terminal domain of ezrin Show all	Enzymes Kinases THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0006468 [protein phosphorylation] GO:0016477 [cell migration] GO:0030027 [lamellipodium] Show all	742 aa 82.9 kDa	No	0