Cell atlas - FUCA2 - The Human Protein Atlas

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FUCA2

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	FUCA2
Gene description	Fucosidase, alpha-L- 2, plasma
Protein class	Enzymes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	FUCA2 (HGNC Symbol)
Synonyms	dJ20N2.5, MGC1314
Description	Fucosidase, alpha-L- 2, plasma (HGNC Symbol)
Entrez gene summary	This gene encodes a plasma alpha-L-fucosidase, which represents 10-20% of the total cellular fucosidase activity. The protein is a member of the glycosyl hydrolase 29 family, and catalyzes the hydrolysis of the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. This enzyme is essential for Helicobacter pylori adhesion to human gastric cancer cells. [provided by RefSeq, Aug 2010]
Chromosome	6
Cytoband	q24.2
Chromosome location (bp)	143494811 - 143511690
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000001036 (version 83.38)
Entrez gene	2519
UniProt	Q9BTY2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BTY2
Antibodypedia	FUCA2 antibodies

PROTEIN BROWSER

FUCA2-001	FUCA2-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FUCA2-001 ENSP00000002165 ENST00000002165	Q9BTY2 [Direct mapping] Plasma alpha-L-fucosidase Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004560 [alpha-L-fucosidase activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005975 [carbohydrate metabolic process] GO:0006004 [fucose metabolic process] GO:0009617 [response to bacterium] GO:0016139 [glycoside catabolic process] GO:0070062 [extracellular exosome] GO:2000535 [regulation of entry of bacterium into host cell] Show all	467 aa 54.1 kDa	Yes	0
FUCA2-003 ENSP00000398119 ENST00000451668	Q7Z6V2 [Direct mapping] Plasma alpha-L-fucosidase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004560 [alpha-L-fucosidase activity] GO:0005975 [carbohydrate metabolic process] Show all	109 aa 12.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.